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CORE--CELL AND ANIMAL MODEL

CORE--CELL AND ANIMAL MODEL
核心--细胞和动物模型
批准号：
6651765
负责人：
RANDALL H KRAMER
金额：
$6.07万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
项目状态：
已结题
起止时间：
2002-06-01 至 2003-05-31
来源：
https://reporter.nih.gov/project-details/6651765
关键词：
biomedical facility cell line disease /disorder model keratinocyte laboratory mouse mouth neoplasms neoplastic growth squamous cell carcinoma tissue /cell culture transfection

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中文摘要
翻译
本项目个别提出的几个研究项目的重要部分依赖于使用人类口腔鳞状细胞癌细胞和动物模型来研究口腔癌的发展和进展。细胞和动物模型核心将为这些研究提供所需的材料。恶性和正常的角化细胞细胞系，这是必不可少的工具提出的研究是可用的。此外，Core B将协助使用逆转录病毒载体转染细胞，并进行肿瘤侵袭和迁移试验。核心设施的另一项重要任务是提供几种不同的口腔癌动物模型，用于研究口腔癌的发展、进展和侵袭/转移。
英文摘要
Important parts of several of the individually proposed research programs of this Program Project depend on the use of human oral squamous cell carcinoma cells and animal models for oral cancer development and progression. The Cell and Animal Model Core will provide the material required for these studies. Both malignant and normal keratinocyte cell lines, which are essential tools for the proposed studies are available. In addition, Core B will assist in the transfection of cells using retroviral vectors and in the performance of tumor invasion and migration assays. Another important task of the Core Facility will to make available several different animal models of oral cancer for the study of development, progression and invasion/metastasis.
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