Core--Mouse transplantation

Core B旨在为几个品系的小鼠提供集中的、专门的动物护理，包括繁殖群体和购买的动物。我们的研究需要培育免疫缺陷和转基因小鼠，因为这些菌株中的许多都没有商业上的可用性，要么是我们研究所需的数量，要么根本没有。大量的小鼠被移植和监测植入，代表了这个核心的另一个主要功能。此外，Core B将为在该集中核心支持下培育的转基因小鼠提供基因分型。我们相信，为这些服务集中提供专业知识在科学上和经济上都是高效的，更重要的是，使所有项目能够快速有效地使用几种复杂的小鼠移植模型。

Core B is designed to provide centralized, specialized animal care for several strains of mice to include breeding colonies and purchased animals. Breeding of immuno-deficient and transgenic mice is required for our studies, as many of these strains are not commercially available, either in the quantities needed for our studies or at all. The large number of mice to be transplanted and monitored for engraftment represents the other major function of this core. In addition Core B will provide genotyping for transgenic mice bred under the auspices of this centralized core. We believe providing the expertise centrally for these service is efficient both scientifically and financially, and more important, makes is possible for all Projects to make rapid and effective use of several sophisticated mouse transplantation models.