CORE--INCEPTION COHORT OF RHEUMATOID ARTHRITIS PATIENTS

该核心将建立、维持并提供初始队列，总计超过1500名类风湿性关节炎（RA）患者在其疾病的第一年内入组，并将在每六个月的完整健康评估问卷（HAQ）管理下使用标准ARAMIS方案对这些患者进行随访，为期9年的纵向随访。这些队列(1)大，(2)广泛代表性，(3)地理上不同，(4)包含可选的管理策略，(5)包含DNA分型数据（DRBI *0401和*0404），(6)包括标准化的中心实验室CRP和类风湿因子测定，(7)包含冷冻细胞和血清，用于未来的研究，(8)通过使用新可用的蛋白质微阵列技术对储存的血清进行研究，可以搜索RA的病原体。(9)包括无排除的连续就诊患者，（10）保持长期随访，包括在发病4年和8年的手部x线片的标准化读数。核心任务建立在医生和患者招募以及长期维护大型数据集的研究者和工作人员技能之上。这些初始队列将为支持项目1、2、3和4以及与其他研究人员的国家和国际合作提供独特和强大的资源。

This Core will establish, maintain, and provide access to inception cohorts totaling over 1500 rheumatoid arthritis (RA) patients enrolled within their first year of disease and will follow these patients using standard ARAMIS protocols within full Health Assessment Questionnaire (HAQ) administration each six months, for a period of longitudinal follow-up of nine years. These cohorts are (1) large, (2) broadly representative, (3) geographically diverse, (4) encompass alternative management strategies, (5) contain DNA typing data (DRBI *0401 and *0404), and (6) include standardized central laboratory determination of CRP and Rheumatoid Factor, (7) contain frozen cells and serum for future studies, (8) enable search for causative agents in RA through use of newly available protein micro-array technology on stored serum, (9) consist of consecutively seen patients without exclusions, and (10) be maintained for long-term follow-up, including standardized reading of hand radiographs at 4 and 8 years of disease. The Core tasks builds upon investigator and staff skills at physician and patient recruitment and in maintenance of large data sets over the long- term. These inception cohorts will provide a unique and powerful resource in support of Projects 1, 2, 3 and 4 and for national and international collaborations with other investigators.