The synthesis of small cycloalkyl boronic esters

小环烷基硼酯是合成化学中有价值的结构基序，因为它们的环应变诱导的刚性碳支架赋予了取代基的空间定义。硼酯也可以作为进一步功能化的手柄。它们的立体控制合成可以通过应变释放和环扩张/收缩化学来实现。由易于获得的5元环硼酸配合物通过环收缩合成具有医学意义的取代环丁基硼酯。

Small cycloalkyl boronic esters are valuable structural motifs in synthetic chemistry, owing to the spatial definition of substituents imparted by their ring strain-induced rigid carbon scaffold. The boronic ester can also act as a handle for further functionalisation. Their stereocontrolled synthesis can be achieved through strain-release and ring expansion/contraction chemistry.The synthesis of medicinally relevant substituted cyclobutyl boronic esters from easily accessible 5 membered ring boronate complexes via a ring contraction is to be investigated.