Visual Dysfunction and Quality of Life in MS

描述：视力障碍是导致患者症状的主要原因， 多发性硬化症（MS）。尽管视力对残疾的重要性 MS的健康相关生活质量（HRQOL），视觉测量 在MS试验中的功能仅限于Snellen视力的测量。 MS新疗法对视力的影响程度并不 已知的，并已难以评估使用传统的措施， 神经损伤尚未检查MS的视觉特征， 视功能与整体神经功能障碍和视力的关系-以及 MS患者的疾病特异性HRQOL尚未在一个大的， 异质性队列本提案将实现以下具体目标： 目的： 1.在大型队列（400例患者）中定义MS的视觉特征，以及 确定哪些措施最好地识别MS患者的视觉功能障碍。 最能区分MS患者与年龄匹配对照组的视力测试 一组将从五个候选措施中确定，使用分析 方差分析（ANOVA），受试者工作特征曲线（ROC）面积分析， 判别函数分析。视觉功能测量将包括 视觉敏锐度、对比字母敏锐度、对比敏感度、色觉，以及 视野视力评分与总体神经功能缺损的关系 （扩展残疾状态量表，MS功能综合评分）也将 使用线性回归和相关技术进行检查。 2.确定视功能与视力和疾病特异性的关系 MS患者的HRQOL。将采用线性回归和相关技术， 用于确定视力评分与视力和疾病特异性 HRQOL评分，使用多发性硬化症生活质量量表（MSQLI） 和25项国家眼科研究所视觉功能问卷（VFQ-25）。 拟议的研究将大大有助于我们了解 多发性硬化症的视觉功能障碍及其与神经功能的关系 对视力和疾病特异性HRQOL的影响。该项目的成果还将 为MS研究和临床试验提供先进的结果评估， 更有效地监测和开发MS疗法。这项建议会 为MS的未来视觉研究提供了重要基础， 包括纵向评估。

DESCRIPTION: Visual impairment is a leading cause of symptoms in patients with multiple sclerosis (MS). Despite the importance of vision to disability and health-related quality of life (HRQOL) in MS, the measurement of visual function in MS trials has been limited to measures of Snellen visual acuity. The extent to which vision has been affected by new therapies for MS is not known, and has been difficult to assess using traditional measures of neurologic impairment. The visual profile of MS has not been examined, and the relation of visual function to overall neurologic impairment and to vision- and disease-specific HRQOL in patients with MS has not been determined in a large, heterogeneous cohort. This proposal will accomplish the following specific aims: 1. Define the visual profile of MS in a large cohort (400 patients), and determine which measures best identify visual dysfunction in patients with MS. The vision tests which best distinguish MS patients from an age-matched control group will be identified from among five candidate measures using analysis of variance (ANOVA), receiver operating characteristic curve (ROC) area analysis, and discriminant function analysis. Visual function measures will include visual acuity, contrast letter acuity, contrast sensitivity, color vision, and visual field. The relation of vision scores to overall neurologic impairment (Expanded Disability Status Scale, MS Functional Composite scores) will also be examined using linear regression and correlation techniques. 2. Determine the relation of visual function to vision- and disease-specific HRQOL in patients with MS. Linear regression and correlation techniques will be used to determine the relation of vision scores to vision- and disease-specific HRQOL scores, using the Multiple Sclerosis Quality of Life Inventory (MSQLI) and the 25Item National Eye Institute Visual Function Questionnaire (VFQ-25). The proposed research will contribute significantly to our understanding of visual dysfunction in MS, its relation to neurologic function, and its impact on vision- and disease-specific HRQOL. Results from this project will also advance outcomes assessment for MS research and clinical trials, allowing for more efficient monitoring and development of MS therapies. This proposal will provide a crucial foundation for future studies of vision in MS that will involve longitudinal assessment.