Neurologic Clinical Epidemiology Training Program

描述（申请人提供）：宾夕法尼亚大学医学院（SOM）临床流行病学与生物统计中心（CCEB）和神经内科，与费城儿童医院神经内科儿科合作，提出了一个创新性的神经内科临床流行病学博士后培养计划。宾大和SOM提倡一种学术环境，鼓励基础和临床研究，并将其视为有吸引力的职业道路。该机构还从全国其他机构吸引学员，从而促进思想和指导方式的交流。本课程旨在培养已经接受过神经病学培训的临床医生，使其成为严谨、独立的学术研究人员，能够使用流行病学中可用的一系列方法来解决有关神经疾病的病因、预后、预防和早期检测、治疗、临床经济学、技术评估、医疗决策和患者护理质量的临床研究问题。具体来说，学员将把临床流行病学的方法应用于神经病学的广泛亚专业，包括神经眼科、多发性硬化症、神经肿瘤学、癫痫、认知神经病学、中风和运动障碍。两到三年的培训课程包括临床流行病学、研究方法学、生物统计学和神经临床流行病学；关注神经学研究问题的期刊俱乐部和临床研究会议；广泛的独立阅读；参加CCEB、神经内科和神经内科（儿科）的研究研讨会；并完成一项独立研究项目。具体而言，该计划旨在：1)提供适合临床研究的研究技术的深入知识；2)为导师提供临床流行病学和神经病学研究方面的研究经验；3)汇集CCEB、神经内科和神经内科（儿科）的教员和研究员。学员将获得临床流行病学理学硕士（MSCE）学位课程，该课程由CCEB管理。该计划的优势在于：1)CCEB长期以来成功的研究培训计划；2)提供给学员的综合课程设置和研究项目；3) CCEB、神经内科、神经内科（儿科）之间的合作关系；4)以及一大批经验丰富的项目主管和教师导师，他们都有成功的培训记录。此外，CCEB、神经内科和神经内科（儿科）的教师拥有广泛丰富的专业知识；可用于研究项目和培训的众多现有大型数据库；广泛的专业分析能力可用于临床研究（即临床试验、病例对照、队列研究）；学院致力于合作研究和培训，为这个培训项目提供了一个理想的环境。

DESCRIPTION (provided by applicant): The Center for Clinical Epidemiology and Biostatistics (CCEB) and the Department of Neurology of the University of Pennsylvania (Penn) School of Medicine (SOM), in collaboration with the Department of Pediatrics, Division of Neurology, of Children's Hospital of Philadelphia propose to develop an innovative postdoctoral neurologic clinical epidemiology training program. Penn and the SOM promote an academic environment in which basic and clinical research are encouraged and viewed as attractive career paths for trainees. The institution also attracts trainees from other institutions nationwide, thus promoting exchange of ideas and mentoring styles. This program is specifically designed to train clinicians already trained in neurology to be rigorous, independent academic investigators able to use the range of approaches available in epidemiology to address clinical research issues regarding the etiology, prognosis, prevention and early detection, treatment, clinical economics, technology assessment, medical decision making, and quality of patient care of neurologic diseases. Specifically, trainees will apply the methods of clinical epidemiology to a broad spectrum of sub-specialties within Neurology, including neuro-ophthalmology, multiple sclerosis, neuron-oncology, epilepsy, cognitive neurology, stroke, and movement disorders. The two- to three-year training program consists of required courses in clinical epidemiology, research methodology, biostatistics, and neurologic clinical epidemiology; journal clubs and clinical research conferences focusing on research issues in neurology; extensive independent readings; attendance at and participation in research seminars at the CCEB, Department of Neurology, and Division of Neurology (Pediatrics); and the completion of an independent research project. Specifically, the program is designed to: 1) provide in-depth knowledge of the research techniques appropriate to clinical research; 2) provide research experience with mentors in clinical epidemiology and neurology research; and 3) bring together faculty and fellows in the CCEB, the Department of Neurology, and the Division of Neurology (Pediatrics). Trainees matriculate in the Master of Science in Clinical Epidemiology (MSCE) degree program, which is managed by the CCEB. Strengths of the proposed program are: 1) the long history of successful research training programs in the CCEB; 2) the comprehensive course offerings and research programs that are available to trainees; 3) the collaborative links that exist among the CCEB, the Department of Neurology, and the Division of Neurology (Pediatrics); 4) and an extensive set of experienced program directors and faculty preceptors with successful training records. In addition, the availability of the broad range of rich expertise of the faculties in the CCEB, Department of Neurology, and Division of Neurology (Pediatrics); numerous existing large databases available that can be used for research projects and training; a broad array of specialized analytic capabilities available for clinical studies (i.e., clinical trials, case-control, cohort research); and the faculties' commitment to collaborative research and training, provide an ideal environment for this training program.