Blood Pressure in Postmenopausal Women: A GCRC Study

描述（由申请人提供）：这是一份针对Ellen Seely医学博士的中期职业调查员（K 24）提案。该提案的目标有三个。首先，它将增加西利博士的研究深度，使研究者能够接受人类遗传学方面的进一步高级培训。其次，这将给研究者提供支持的时间来正式培训年轻研究者在激素控制血压领域的以患者为导向的研究。第三，它将允许研究者利用她作为普通临床研究中心（GCRC）的副项目主任的经验，教授下一代以患者为导向的研究人员使用各种基于GCRC的调查技术来使用GCRC进行人类病理生理学的研究。Seely博士的研究课题“绝经后妇女的血压：一项GCRC研究”为K24提供了肥沃的土壤。在美国，高血压影响着超过2000万女性，其中大多数是绝经后妇女。虽然高血压在男性和女性中都有明显的遗传因素，但绝经后女性的发病率明显高于男性，这表明绝经前状态的激素环境可能对高血压的表现有保护作用。Seely博士的研究计划的总体目标是利用GCRC对绝经后妇女高血压的病理生理学进行详细研究。Seely博士计划确定肾素-血管紧张素-醛固酮系统（RAAS）的基因多态性是如何受到雌二醇的影响的。RAAS是血压的主要调节因子。了解雌二醇与导致血压降低的RAAS特异性多态性的相互作用，可能有助于开发具有降压作用的选择性雌激素受体调节剂。因此，这项提案的资助将允许Seely博士扩展她自己的研究生涯，同时为她提供时间来扩大她的导师角色。

DESCRIPTION (provided by applicant): This is a Mid-Career Investigator (K 24) proposal for Ellen Seely, MD. The goal of this proposal is threefold. First, it would increase the depth of Dr. Seely's research by enabling the investigator to receive further advanced training in human genetics. Second, it would give the investigator the supported time to formally train young investigators in patient-oriented research in the field of hormonal control of blood pressure. Third, it would allow the investigator to use her experience as Associate Program Director of the General Clinical Research Center (GCRC) to teach the next generation of patient-oriented researchers about the use of a GCRC for the study of human pathophysiology using varied GCRC-based investigative techniques. Dr. Seely's research topic "Blood Pressure in Postmenopausal Women: a GCRC Study" serves as fertile ground for a K24. Hypertension affects over 20 million women in the United States and the majority of these women are postmenopausal. Although there is clearly a genetic component to hypertension in both men and women, its incidence increases dramatically in women following menopause superceding that in men and suggests that the hormonal milieu of the premenopausal state may be protective against the manifestation of hypertension. The overall goal of Dr. Seely's research plan is to utilize the GCRC for detailed studies of the pathophysiology of hypertension in postmenopausal women. Dr. Seely plans to determine how polymorphisms of genes of the renin-angiotensin-aldosterone system (RAAS), a major regulator of blood pressure, are influenced by estradiol. An understanding of the interaction of estradiol with specific polymorphisms of the RAAS that lead to blood pressure lowering may enable the development of selective estrogen receptor modulators that have antihypertensive effects. Thus, funding of this proposal will allow Dr. Seely to expand her own research career and simultaneously provide time to expand her mentorship role.