CELL BIOLOGY

描述：细胞生物学项目由16名成员组成，他们的主要 目的是了解控制细胞的信号机制 增殖和分化，并研究它们的错乱 癌症的机制。目标是提供一个识别的框架 和中和癌症生长基础的改变。 细胞生物学项目在此之前经历了快速增长 授权期。当时招募了六名计划成员 大大增加了该计划的规模。本期已有 作为其目标(1)整合和发展那些较新的职业 成员，(2)招募计划的一名新成员(Robert Fisher博士)，以及 (3)联合招聘人类遗传学项目主任(Lucio博士 卢扎托)。招募罗伯特·费舍尔博士的决定是由该项目做出的 执行委员会，由资深教职员工组成。这个委员会开会 每两个月讨论一次计划，评估研究方向和 初级教师的工作效率，并对他们进行晋升评估。高管们 委员会聘请费希尔博士是因为他作为一名生物化学家研究 细胞周期，这是这个项目的一个重点领域。 计划成员从National获得总计160万美元的直接成本 科学基金会(NSF)、美国癌症学会(ACS)、其他NIH研究所、 和国家情报局。有13个奖助金，包括两个乳癌孢子 子项目，两个来自国家科学基金会的赠款，三个来自美国国家科学委员会的拨款，一个关于 U-19，以及五项R01类型的赠款，包括授予马萨格博士的功勋奖。 促进互动的机制包括由主席发起的、 每周，“细胞调节工作进行中”研讨会系列。这涉及到 中心约30名S基础和临床研究人员来自不同的 课程，包括这个课程的所有教职员工。此外， 主席每年与每位教职员工会面，评估进展情况。这个 计划成员在他们的研究中使用多个核心设施。发展中 资金被用来为两个实验室提供启动资金 这两个人现在都得到了资助。

Description: The Cell Biology Program consists of 16 members whose major objective is to understand the signal mechanisms that control cell proliferation and differentiation and study the derangement of these mechanisms in cancer. The goal is to provide a framework for identification and neutralization of the alterations underlying cancerous growth. The Cell Biology Program underwent rapid growth just prior to the present grant period. The recruitment of six program members at that time significantly increased the size of the program. The current period has had as its objectives (1) to integrate and develop the careers of those newer members, (2) to recruit one new member of the program (Dr. Robert Fisher), and (3) to co-recruit the Director of the Human Genetics Program (Dr. Lucio Luzzatto). The decision to recruit Dr. Robert Fisher was made by the program Executive Committee, which consists of senior faculty. This committee meets bi-monthly to discuss the program and assess the research direction and productivity of junior faculty and evaluate them for promotion. The Executive Committee recruited Dr. Fisher for his expertise as a biochemist studying the cell cycle, an area of emphasis in this program. Program members receive a total of $1.6 million in direct costs from National Science Foundation (NSF), American Cancer Society (ACS), other NIH institutes, and the NCI. There are thirteen grants, including two Breast Cancer SPORE sub-projects, two grants from the NSF, three from the ACS, a sub-project on a U-19, and five R01-type grants, including a MERIT award to Dr. Massague. The mechanisms for promoting interaction includes a Chairman-sponsored, weekly, "Cell Regulation Work-in-Progress" seminar series. This involves approximately 30 of the Center?s basic and clinical investigators from various programs, including the entire faculty of this program. In addition, the Chairman meets with each faculty member yearly to assess progress. The program members use multiple core facilities in their research. Developmental funds were used to provide start-up funding for the laboratories of two investigators during the current cycle, both of whom are now funded.