IMMUNOPATHOGENESIS OF MYCOBACTERIUM & SIV COINFECTION IN MACAQUES

艾滋病毒和结核分枝杆菌的合并感染与 活动性结核病发病率高， 临床艾滋病的发展阐明了 由HIV/M结核病引起的免疫致病性事件 因此，合并感染对于了解 这种混合感染的免疫后遗症我们已经证明， SIV与牛分枝杆菌卡介苗混合感染 (BCG)发展出一种类似于艾滋病相关结核病的综合症 这个SIV/BCG共感染模型，我们计划研究 艾滋病病毒与分枝杆菌相互作用免疫发病机制 结核病的演变出版物Zou Z，Halloran M， 李-帕里茨D，沈L，西蒙M，沈Y，陈志文 细菌超抗原对猕猴TCR谱系的影响J Immunol， 160：5170-5180，1998年

Coinfection with HIV and Mycobacterium tuberculosis is associated with high rates of active tuberculosis and possibly an acceleration of the progression to clinical AIDS Elucidating the interplay of the immunopathogenic events that occur as a result of HIV/M tuberculosis coinfection is, therefore, of central importance for understanding the immune sequelae of this coinfection We have shown that macaques coinfected with SIV and Mycobacterium bovis Bacille Calmette-Guerin (BCG) develop a syndrome similar to AIDS-related tuberculosis Using this SIV/BCG coinfection model, we plan to study the immunopathogenesis of AIDS virus interactions with mycobacteria and the evolution of tuberculosis Publication Zou Z, Halloran M, Lee-Parritz D, Shen L, Simon M, Shen Y, Chen ZW In vivo effects of a bacterial superantigen on macaque TCR repertoires J Immunol, 160:5170-5180, 1998