The Molecular Basis of Head and Neck Cancer Therapy

描述（由申请人提供）：一个全面的多学科 翻译研究计划提出，将显着提高 头颈癌的诊断、治疗和预防，同时减少 与这种疾病相关的发病率和死亡率。在这方面的重点是 卓越研究的专业计划（SPORE）是发展 创新的器官保存治疗方法， 制定、测试和纳入健全的预防战略 采用系统性治疗方法解决远处转移， 第二大癌症。五个项目和三个发展项目 项目将探索化疗和放疗的分子基础， 治疗决定（项目1、2、5）和远处转移风险 （项目3、4、5）或肿瘤复发/第二原发癌（项目3）。 这个孢子的总体假设是，未来的治疗进展 头颈部癌症的预防将基于更好地了解 个体特征性的分子和遗传改变 肿瘤的基于这一假设，更具体和更少的病态治疗 将开发和测试优化器官保存的方案， 预防复发和治疗播散性疾病。大力强调 在这方面，SPORE被置于职业发展和试点研究项目 发展，以确保不断创新和增加新的 致力于头颈部转化研究的研究人员。有限 还提出了若干关键基础设施核心。这个头 Neck SPORE是密歇根大学的一个完全集成的组成部分 综合癌症中心。我们建议广泛使用癌症中心核心 设施、临床和实验室资源以及研究人员，并 经验丰富的癌症中心领导。经验丰富的优秀团队 临床/基础合作者与高机构承诺相结合， 优先，广泛的患者资源提供了一个杰出的研究 确保成功实现SPORE总体目标。

DESCRIPTION (provided by applicant): A comprehensive multidisciplinary translational research program is proposed that will significantly improve the diagnosis, treatment and prevention of head and neck cancer while decreasing morbidity and mortality associated with this disease. The emphasis in this Specialized Program of Research Excellence (SPORE) is the development of innovative organ preservation treatment approaches that will reduce patient morbidity and to develop, test and incorporate sound prevention strategies with systemic treatment approaches that will address distant metastases and second primary cancers. Five proposed projects and three developmental projects will explore the molecular basis for chemotherapy and radiation treatment decisions (Projects 1, 2, 5) and the risk of distant metastases (Projects 3, 4, 5) or tumor recurrence/second primary cancer (Project 3). The overall hypothesis of this SPORE is that future advances in the treatment and prevention of head and neck cancer will be based on better understanding of specific molecular and genetic alterations characteristic of individual tumors. Based on this hypothesis, more specific and less morbid treatment regimens will be developed and tested that optimize organ preservation, prevention of recurrence and therapy of disseminated disease. Strong emphasis in this SPORE is placed on career development and pilot research project development to ensure ongoing innovation and increases in the numbers of new investigators dedicated to head and neck translational research. A limited number of critical infrastructure cores are also proposed. This Head and Neck SPORE is a fully integrated component of the University of Michigan Comprehensive Cancer Center. We propose extensive use of Cancer Center core facilities, clinical and laboratory resources and investigators, and draw heavily on experienced Cancer Center leadership. Superb teams of experienced clinical/basic collaborators combined with high institutional commitment and priority, and extensive patient resources provide an outstanding research environment that will ensure success in achieving overall SPORE goals.