NEUROBIOLOGY OF TROPANE ANALOG

项目11是一个协调的药物发现计划， 中心内所代表的一系列分析能力。这是一个 许多实验室继续开展合作， 以前在一般核心结构下分组。小说托烷 由Huw Davies博士的乙烯基卡宾化学产生的类似物将被 筛选其神经化学效力，特异性和行为 采取行动，努力确定具有科学意义的化合物， 性质和/或治疗价值。将筛选化合物的 对单胺转运蛋白的特异性和有效性， 蔡尔德斯和班尼特博士的亲脂性研究所选化合物将 其特征在于它们对局部葡萄糖代谢的影响。 Porrino的实验室;她还将评估运动刺激效应 并确定它们的时间进程史密斯医生会检查 选定的托烷类化合物对细胞外多巴胺和5-羟色胺的影响 通过微透析研究。自我给药研究 罗伯茨博士进行的研究将检查 特定的托烷类似物，这将是有用的分析基本 关于精神兴奋剂强化的神经生物学问题， 潜在的治疗目标。

Project 11 is a coordinated drug discover program that involves the full range of analytical capabilities represented within the Center. It is a continuation of the collaborative efforts of many laboratories that were previously grouped under a general core structure. The novel tropane analogs produced by the vinylcarbenoid chemistry of Dr. Huw Davies will be screened for their neurochemical potency, specificity and behavioral actions in an effort to identify compounds with scientifically interesting properties and/or therapeutic value. Compounds will be screened for their specificity and efficacy at monoamine transporters and for their lipophilicity by Drs. Childers and Bennett. Selected compounds will be characterized for their effects on regional glucose metabolism in Dr. Porrino's laboratory; she will also assess the locomotor stimulant effects on these tropanes and determine their time course. Dr. Smith will examine the effects of selected tropanes on extracellular dopamine and serotonin levels through microdialysis studies. Self-administration studies conducted by Dr. Roberts will examine the relative reinforcing efficacy of specific tropane analogues that will be useful for the analysis of basic neurobiological questions concerning psychostimulant reinforcement and as potential therapeutic targets.