UCSF PROSTATE CANCER SPORE

该申请代表了一种跨学科的方法来改善前列腺癌的预防、诊断和治疗。UCSF的基础科学家和临床研究人员在细胞和分子生物学、免疫学、遗传学、信息学、生物统计学以及进行前列腺癌的I期研究方面具有不同的才能，他们正在共同努力解决这种疾病的重要问题。有四个项目专门设计用于改善晚期前列腺癌的治疗：1)抗ctla4抗体；2)突变腺病毒和放射治疗；3)针对前列腺癌抗原的重组人抗体；4)突变端粒酶。其中一个项目将利用抗体基因多样性文库和噬菌体展示技术鉴定新的前列腺癌抗原。此外，一个项目的重点是确定前列腺癌的遗传畸变负责疾病的发展和进展。一个相关项目的重点是鉴定修饰基因，这些修饰基因决定患者是否会发生前列腺癌转移。几个核心将为项目提供关键支持，包括：信息学、临床研究、动物技术；组织获取、储存和管理。此外，最近成立的前列腺癌倡导核心的成员将与SPORE研究人员一起设计和实施临床试验的最佳方法。

APPLICANT'S DESCRIPTION The application represents an interdisciplinary approach to improving prevention, diagnosis, and treatment of prostate cancer. UCSF basic scientists and clinical investigators with diverse talents in cell and molecular biology, immunology, genetics, as well as informatics, biostatistics, and conducting phase I studies in prostate cancer are working together to address important problems in this disease. Four projects specifically are designed to improve treatment of advanced prostate cancer using either 1) anti-CTLA4 antibodies 2) mutant adenoviruses and radiation therapy, 3) recombinant human antibodies against prostate cancer antigens, and 4) mutant telomerases. One of the projects will identify new prostate cancer antigens using antibody gene diversity libraries and phage display. In addition, one project is focused on identifying the genetic aberrations in prostate cancer responsible for development and progression of the disease. A related project is focused on identifying modifier genes which determine whether patients develop prostate cancer metastases. Several Cores will provide critical support to the Projects including Cores focused on: Informatics, Clinical Research, Animal Technology; Tissue acquisition and storage, and Administration. In addition, members of a recently formed Prostate Cancer Advocacy Core will work with SPORE investigators to design, and implement optimal approaches to clinical trials.