OCULAR HYPERTENSION TREATMENT STUDY (OHTS)

这是一份申请，请求支持我们的组织成为 参与眼压治疗研究的临床中心 (OHTS)。OHTS是一项多中心随机分配临床试验 旨在检验这样一种假设，即医学上的眼内复位 压力可预防或延缓青光眼视觉系统的发病 高眼压患者的眼部损害。OHTS的完整细节 基本原理、设计和方法包含在OHTS的主要应用程序和 程序手册。 本建议书提供了校长能力的文档 调查员和协查人员将筛查足够数量的 高眼压患者将在一年内登记至少100名患者 24个月的期限。我们将在以下赞助下组织这项工作 大学眼科顾问研究与教育基金会 华盛顿的。 我们致力于OHTS的需要和理由。我们包括 使用此应用程序文档，了解我们的 组织根据OHTS的细节进行研究 程序手册。我们登记的大部分患者将来自我们的 私人青光眼专科诊所。我们已经开始运作了 成功完成了晚期青光眼干预研究(AGIS)。我们 将该正常运作的组织纳入我们提议的参与 OHTS。在我们的研究计划中，我们将我们所在地区的组织列为潜在组织 患者登记和随机分组的外部转诊来源 在OHTS接受治疗。我们与这些组织的关系是 它们是我们农业地理信息系统活动的富有成效的来源。

This is an application for support for our organization to become a participating Clinical Center in the Ocular Hypertension Treatment Study (OHTS). The OHTS is a multicenter random assignment clinical trial designed to test the hypothesis that medical reduction of intraocular pressure prevents or delays the onset of glaucomatous visual system damage in ocular hypertensive patients. The complete details of the OHTS rationale, design, and methods are in the OHTS lead application and Manual of Procedures. This proposal provides documentation of the ability of the Principal Investigator and the Coinvestigators to screen sufficient numbers of ocular hypertensive individuals to enroll at least 100 patients over a 24-month period. We shall organize for this effort under sponsorship of the University Ophthalmic Consultants Research and Educational Foundation of Washington. We are committed to the need and justification of the OHTS. We include with this application documentation of the capabilities of our organization to conduct the study in accord with the details of the OHTS Manual of Procedures. Most of our enrolled patients will come from our private, glaucoma subspeciality practices. We have already functioned successfully for the Advanced Glaucoma Intervention Study (AGIS). We bring that functioning organization to our proposed participation in the OHTS. In our Research Plan we list organizations in our area as potential outside referral sources for patients for enrollment and randomization to treatment in the OHTS. Our relationship with these organizations is established; they have been productive sources in our AGIS activity.