BRIAN INJURY TRAINING GRANT

描述(由申请人提供)：拟议的计划将培训医学博士、博士和医科学生研究人员，掌握最先进的技术，以调查中枢神经系统(CNS)损伤的分子和细胞机制。受训人员将是：1)参与宾夕法尼亚大学神经外科住院医师培训计划的医生；2)曾接受过分子生物学培训的博士科学家；或3)参加宾夕法尼亚大学独特临床神经科学跟踪计划的选定医学生。本课程将提供分子神经生物学的背景和培训，并介绍可应用这些新技术的中枢神经系统疾病。该计划将是一个以实验室为基础的研究-培训计划，包括在互动和支持性环境中的新分子生物学技术的经验。该机构在基础和临床神经科学、神经退行性变、中枢神经系统损伤和包括基因治疗在内的分子生物学方面有广泛的教学计划，将为每个受训人员单独设计课程，以补充实验室经验。每个受训者将设计和完成一个独立的项目，提供设计和分析实验以及展示和发布结果的经验。每周的实习生研究研讨会和每月的教师/实习生小型研讨会为教师培训者和实习生之间提供持续的交流和交流。该项目将由宾夕法尼亚大学在各自领域处于领先地位的教员培训人员运营，他们代表的学科包括中枢神经系统缺血和创伤、神经退行性疾病、遗传性神经疾病、脱髓鞘疾病、癫痫、神经麻醉学、分子病毒学、基因疗法和分子药理学。每个受训者为主要研究项目选择一个实验室，但将完全接触其他培训者以获得建议、技术援助和合作。每个培训师都有独立的NIH资金，都有积极的和国际公认的研究计划。宾夕法尼亚大学、维斯塔尔研究所、儿童海滨之家和人类基因组治疗研究所提供的核心服务包括蛋白质测序、寡核苷酸合成、转基因敲除/敲入技术、自动DNA测序、病毒载体构建和基因治疗技术。宾夕法尼亚大学目前没有资助机制来支持这些受训者。这项脑损伤培训补助金(BITG)申请的资金将建立一个新的和重要的基础设施，包括高度合作的教职员工，目的是培训未来的研究科学家和临床医生与一种重要的临床疾病相关的最先进的技术。

DESCRIPTION (provided by applicant): The proposed program will train M.D., Ph.D. and medical student investigators in state-of-the-art techniques to investigate the molecular and cellular mechanisms underlying central nervous system (CNS) injury. The trainees will be: 1) Physicians involved in the University of Pennsylvania Neurosurgical residency-training program, 2) Ph.D. scientists with prior training in molecular biology, or 3) selected medical students who are participating in Penn's unique Clinical Neuroscience Track program. This program will provide background and training in molecular neurobiology and an introduction to CNS disorders where these new techniques can be applied. This program will be a laboratory-based research-training program that includes experience in novel molecular biology techniques in an interactive and supportive setting. The institution has an extensive didactic program in basic and clinical neurosciences, neurodegeneration, CNS injury, and molecular biology including gene therapy, which will be individually designed for each trainee in order to supplement the laboratory experience. Each trainee will design and complete an independent project providing experience in design and analysis of experiments and in the presentation and publication of results. Weekly trainee research seminars and monthly faculty/trainee mini-symposia provide constant interchange and exchange between faculty trainers and trainees. This program will be run by individual faculty trainers who are the leaders in their field at the University of Pennsylvania, representing disciplines such as CNS ischemia and trauma, neurodegenerative diseases, inheritable neurological disorders, demyelinating diseases, epilepsy, neuroanesthesiology, molecular virology, gene therapy, and molecular pharmacology. Each trainee selects one laboratory for the primary research project but will have complete access to the other trainers for advise, technical assistance, and collaboration. Each trainer has independent NIH funding and all have active and internationally-recognized research programs. Core services available within the University of Pennsylvania, Wistar Institute, Children's Seashore House, and the Institute of Human Genome Therapy include protein sequencing, oligonucleotide synthesis, transgenic knock out/ knock in technology, automated DNA sequencing, viral vector construction, and gene therapy techniques. No funding mechanism currently exists at the University of Pennsylvania to support these trainees. The funding of this Brain Injury Training Grant (BITG) application will establish a novel and important infrastructure involving a highly collaborative faculty for the purpose of training future research scientists and clinicians in the state-of-the-art techniques related to an important clinical disease.