Pilot of Two CAM Tratments for Maintenance Wt Loss

描述（由申请人提供）：肥胖的流行程度达到流行病的程度，60%的美国成年人超重或肥胖。肥胖会导致慢性疾病——糖尿病、心血管疾病、高血压、糖尿病、癌症和骨关节炎，并导致医疗保健费用不断上升。减肥可以对减少这些情况产生重大影响。在使用行为疗法开发有效的短期体重减轻项目方面已经做出了大量努力。然而，长期维持体重减少仍然是有问题的——许多人在一年内恢复了失去的体重。迫切需要创新的干预方案，以帮助人们成功地保持体重减轻并与肥胖流行病作斗争。补充和替代医学（CAM）方法——身心、能量治疗和传统中医（TCM）方法——可能对帮助改善维持体重有很大的希望。尽管有长期的历史使用，关于益处和疗效的大量轶事和病例报告信息，合理的作用生物学机制和巨大的消费者兴趣，但很少有关于这些CAM疗法对维持或减少脂肪的评估数据。本研究的目的是在一组超重肥胖个体中试点测试两种CAM治疗的可行性、可接受性和适应症，气功和指压tat，以改善长期维持体重减轻。设计为随机对照三组研究：1)对照组，2)气功维持和3)穴位压- tat维持，每组30名参与者。所有参与者都接受了一个标准的为期12周的行为减肥计划。在此之后，参与者随机接受维持干预，并随访6个月。测量发生在筛查、基线、随机化后12和24小时。结果包括：体重变化、饮食、身体活动、自我报告的维持技术使用情况、对方法的可接受性和满意度，以及各种可能是中介或被干预调节的社会心理参数（生活质量、感知压力等）。这项研究的信息将用于开发一个更大的随机试验，以评估不同的维持方法，以改善长期维持体重损失。

DESCRIPTION (provided by applicant): The prevalence of obesity is at epidemic proportions, 60% of US adults are overweight or obese. Obesity contributes to chronic diseases-diabetes, CVD, hypertension, diabetes, cancer and osteoarthritis and to escalating health care costs. Weight loss can have a substantial impact on reducing these conditions. Substantial efforts have been made in developing effective short-term wt. loss programs using behavioral treatments. However, long-term maintenance of wt. loss continues to be problematic - many individuals regain the wt. lost within a year. Innovative intervention options are critically needed to help people successfully maintain weight loss and to fight the obesity epidemic. Complementary and alternative medicine (CAM) approaches - mind-body, energy healing, and Traditional Chinese Medicine (TCM) approaches - may hold great promise for helping improve the maintenance of wt. loss. Despite long historical use, significant anecdotal and case report information on benefits and efficacy, plausible biologic mechanisms for action and great consumer interest, there is little data available on the evaluation of these CAM therapies for wt. maintenance or wt. loss. The goal of this study is to pilot test in a group of overweight-obese individuals the feasibility and acceptability and indications of efficacy of two CAM treatments, qigong, and acupressure-TAT, for improving long term maintenance of wt. loss. The design is a randomized, controlled 3-arm study: 1) Control, 2) qigong maintenance and 3) Acupressure-TAT maintenance, with 30 participants per group. All participants receive a standard 12-week behavioral wt. loss program. Following this, participants are randomized to receive the maintenance interventions and are followed for 6 months. Measurements occur at screening, baseline, and 12, and 24 post-randomization. Outcomes include: wt. change, diet, physical activity, self-reported use of the maintenance techniques, acceptability and satisfaction with the approaches as well as a variety of psychosocial parameters that may be mediators or moderated by the intervention (QOL, perceived stress, etc.). Information from this study will be used to develop a larger randomized trial to evaluate different maintenance approaches to improve long-term maintenance of wt. loss.