ADOLESCENT MEDICINE TRIALS UNIT AT CHOP

费城儿童医院（CHOP）拟议的青少年医学跟踪单元（AMTU）将成为艾滋病毒/艾滋病干预青少年医学跟踪网络的一个站点。在CHOP研究中心，将确定至少75名12至24岁的HIV阳性和125名HIV阴性干预研究参与者，并将其作为未来研究的潜在人群。试验组的工作人员将负责筛选所有参与者，并负责开发和维护当地项目的中央管理数据库。CHOP AMTU的工作人员将为当地项目的方案制定做出贡献。CHOP AMTU的工作人员将为国家工作方案的制定做出贡献，并将完成AMTU研究中心要求的所有数据收集工作。主要研究者和研究协调员将充分参与网络。AMTU在CHOP的活动的一个核心部分将是向感染艾滋病毒的青年进行宣传。持续的教育、咨询和测试工作，以及维护一个活跃的合作转诊网站网络，将是确保获得所需数量的潜在研究参与者的关键因素。社区教育工作已经在CHOP和一个强有力的临床护理方案感染艾滋病毒的青年将支持AMTU的能力，成为一个充分参与国家努力的网站。CHOP青少年医学部的忙碌青少年护理中心和社区青少年护理外展方案将参与该项目，作为确定适当的艾滋病毒阴性青年进行干预试验的手段。来中心的人将被告知网络的活动，在制定协议的同时将培养他们的参与。费城儿童医院有一个完善的计划，以支持临床研究工作和临床试验，如那些被网络锁定。来自NIH支持的儿科综合临床研究中心、机构支持的临床试验单位、儿科药理学研究单位和Joseph Sakes研究所的技术和结构支持都将提供给CHOP的AMTU。

The proposed Adolescent Medicine Trails Unit (AMTU) at The Children's Hospital of Philadelphia (CHOP) will be one site for the Adolescent Medicine Trails Network for HIV/AIDS Interventions. At the CHOP site, at least 75 HIV-positive and 125 HIV -negative intervention study participants between the ages of 12 to 24 years will be identified and maintained as a potential population for future studies. The Trail Unit staff will be responsible for screening all participates and in the development and maintenance of the central managerial database for the local program. Staff of the CHOP AMTU will contribute to protocol development for the local program. Staff of the CHOP AMTU will contribute to protocol development for the national effort and will complete all data collection efforts required of an AMTU site. The Principle Investigator and Study Coordinator will participate fully in the Network. A central part of the activities of the activities of the AMTU at CHOP will be outreach to HIV-infected youth. Ongoing education, counseling, and testing efforts, as well as the maintenance of an active network of collaborating referral sites, will be critical elements in assuring the availability of the required number of potential research participants. Community education efforts already in existence at CHOP and a strong clinical care program for HIV-infected youth will support the AMTU's ability to be a fully participating site in the national effort. The busy Adolescent Care Center and community adolescent care outreach programs of the Division of Adolescent Medicine at CHOP will be involved in the project as means of identifying appropriate HIV- negative youth for intervention trials. Those coming to the Center will be told about the activities of the Network and their participation will be cultivated while protocols are developed. The Children's Hospital of Philadelphia has a well-developed program to support clinical research efforts and clinical trails like those to be latched by the network. Technical and structural support from the NIH-supported Pediatric General Clinical Research Center, the institutionally-supported clinical trails unit, the pediatric pharmacology research unit, and the Joseph Sakes Research Institute will all be availably to the AMTU at CHOP.