Aerobic Exercise Intervention for Knee Osteoarthritis

描述（由申请人提供）： 关节炎是功能受限的最常见原因之一， 在美国的依赖。骨关节炎患者限制关节 运动和限制活动，以减少他们的症状。传统的， 骨关节炎的保守医学治疗一直致力于改善 通过减少关节疼痛和炎症，维持关节功能状态， 或恢复关节功能。运动作为一种辅助治疗在临床 然而，膝关节骨关节炎患者的管理并不是 一致接受。 相反，运动已被证明是有效的预防和 治疗心血管和代谢紊乱。存在标准准则 有氧运动处方这项研究的重点是确定是否 这些指南也可应用于患有膝关节骨关节炎的个体。 膝关节骨关节炎患者将被随机分为对照组， 步行运动组和固定自行车运动组。的 运动组的个人将被要求每小时运动三次。 每周一年，使用新兴的公共卫生建议， 在成年人和老年人中锻炼。将评估患者结局 使用客观步态分析测量、膝关节X光片来量化关节 间隙狭窄，磁共振成像，一般健康状况 问卷（SF-36）、疾病/部位特异性问卷（WOMAC）和 视觉模拟疼痛量表所有受试者将在第0周和第52周进行研究。 这项工作的中心假设是，有氧运动可以 作为一种有效的非手术治疗选择， 早期膝关节骨关节炎患者。为了评估这个 假设，提出了以下具体目标：具体目标1：确定 有氧运动对膝关节骨性关节炎患者的影响。假设 答：参加运动的患者的临床结局指标会更好 在控制患者中的程序。假设B：较低的 在有效的有氧运动中，肢体功能不会随着时间的推移而下降 程序.具体目标2：确定影响预后的预后因素， 膝关节骨关节炎患者。假设：有效的练习 对于患有退行性关节疾病的成年人， 间室受累、CIA分期、BMI和规定的运动类型。

DESCRIPTION (provided by applicant): Arthritis is one of the most common causes of functional limitation and dependency in the United States. Individuals with osteoarthritis restrict joint motion and limit activity in order to decrease their symptoms. Traditional, conservative medical treatment of osteoarthritis has been directed at improving functional status through reducing joint pain and inflammation and maintaining or restoring joint function. Exercise as an adjunct therapy in the clinical management of patients with osteoarthritis of the knee, however, is not uniformly accepted. In contrast, exercise has been shown to be effective for prevention and treatment of cardiovascular and metabolic disorders. Standard guidelines exist for aerobic exercise prescriptions. The focus of this study is to determine if these guidelines can also be applied to individuals with knee osteoarthritis. Patients with knee osteoarthritis will be randomized into a control group, a walking exercise group, and a stationary cycling exercise group. The individuals in the exercise groups will be required to exercise three times per week for one year using emerging public health recommendations for aerobic exercise in the adult and aging population. Patient outcome will be assessed using objective gait analysis measurements, knee radiographs to quantify joint space narrowing, magnetic resonance imaging, a general health status questionnaire (SF-36), a disease/site specific questionnaire (WOMAC), and a visual-analog pain scale. All subjects will be studied at 0 and 52 weeks. The central hypothesis of this work is that aerobic exercise can be successfully implemented as an effective nonsurgical option for treatment of patients with early stages of knee osteoarthritis. In order to evaluate this hypothesis, the following specific aims are proposed: Specific Aim 1: Determine the effect of aerobic exercise on patients with knee osteoarthritis. Hypothesis A: Clinical Outcome measures will be better in patients enrolled in exercise programs that in control patients. Hypothesis B: Quantitative measures of lower extremity function will not decline over time in an effective aerobic exercise program. Specific Aim 2: Determine prognostic factors that effect outcome in patients with knee osteoarthritis. Hypothesis: A effective exercise prescription for adults with degenerative joint disease is dependent on knee compartment involvement, CIA stage, BMI, and type of exercise prescribed.