CORE--NEUROIMAGING

描述(由申请人提供)：神经影像研究正在发挥越来越重要的作用 在急性卒中患者诊断和治疗中的作用。需要急性成像才能 鉴别出血和缺血，并提供有关脑损伤的位置、程度和机制的重要信息。神经影像研究还提供了评估急性中风患者脑组织功能和生理的唯一可用的、实用的和客观的手段。目前，头部CT研究用于选择静脉溶栓治疗的最佳候选者。越来越多的证据表明，未来可能会使用包括扩散-灌注磁共振成像在内的多模式技术来选择更长时间点的患者进行治疗。研究研究，包括急性中风的临床试验，需要神经成像提供的信息来对合适的患者进行分类，并以定量公正的方式评估结果。加州大学洛杉矶分校的神经成像核心建立在急性中风神经成像方面的当地资源和人员优势之上。该中心将有3个具体目标：1)促进急性中风患者的快速数据采集；2)提供研究解释、处理和分析方面的专业知识，以协助急性患者管理，并作为3个研究项目的结果衡量标准；3)协助加州大学洛杉矶分校中风网络医院优化神经成像数据采集和解释。该核心将确保立即提供24小时的急性头部计算机断层扫描检查。每天为所有急性中风患者提供服务，包括研究解读方面的放射学专业知识。此外，该核心将为多模式CT提供24小时/天的可用性，包括CT血管成像和灌注CT，包括扩散-灌注成像和MR血管成像的多模式MRI，包括经颅多普勒和颈动脉双工成像的超声波，以及数字减影血管成像。神经成像核心将具体协助这三个项目进行图像分析和后处理，包括体积分析。在这些项目中的每一个中，神经成像 在研究设计、实施和结果衡量方面起着关键作用。

DESCRIPTION (provided by the applicant): Neuroimaging studies are playing an ever more critical role in the diagnosis and management of acute stroke patients. Acute imaging is required to differentiate hemorrhage from ischemia and provides important information about the location, extent, and mechanism of cerebral injury. Neuroimaging studies also provide the only available practical and objective means of assessing brain tissue function and physiology in the acute stroke patient. Currently, head CT studies are used to select the best candidates for IV thrombolytic therapy. A growing body of evidence suggests that multimodal techniques, including diffusion-perfusion magnetic resonance imaging, may be used in the future to select patients for treatment at longer time-points. Research studies, including clinical trials for acute stroke, need the information provided by neuroimaging to triage appropriate patients and to assess outcome in a quantitative impartial fashion. The Neuroimaging Core at UCLA builds on local strengths in resources and personnel in acute stroke neuroimaging. The core will have 3 specific aims: 1) To facilitate rapid data acquisition for patients presenting with acute stroke; 2) to provide expertise in study interpretation, processing, and analysis both to assist in acute patient management and as outcome measures in the 3 Research Projects; and 3) to assist UCLA Stroke Network Hospitals in optimizing neuroimaging data acquisition and interpretation. The core will ensure that acute head computed tomography studies are immediately available 24 hrs. per day for all acute stroke patients, including radiologic expertise in study interpretation. Additionally, the core will provide 24 hrs./day availability for multimodal CT, including CT angiography and perfusion CT, multimodal MRI, including diffusion-perfusion imaging and MR angiography, ultrasound including transcranial Doppler and carotid duplex imaging, and digital subtraction angiography. The Neuroimaging Core will specifically assist the three Projects in image analysis and post-processing, including volumetric analyses. In each of these projects, neuroimaging plays a key role in study design, implementation, and outcome measures.