Analysis of Advanced Motion Kinetics and Kinematics, Correlated with Proteomic Approach to Biological Assessment of the Joint

本项目是生物医学工程、细胞生物学和临床整形外科的交叉学科。这是一个可直接翻译的项目，使学生能够发展适用于各种学科的技能，并体验与患者的互动。该学生将使用先进的动作捕捉技术分析患者在膝关节置换手术前后的步态，并量化膝关节的运动范围、肌肉力量、稳定性和步态运动学。学生将主要评估和量化个体患者的生物力学，以及疾病和肌肉无力的程度如何影响他们的运动和进行日常生活活动的能力。当手术完成时，学生将使用个性化的运动学对齐技术和机械对齐技术，专门研究膝关节的关节线和胫骨倾角的前平面运动学变化。关节的生物环境对步态和功能很重要。对膝关节置换手术中获得的滑液进行蛋白质组学分析的方法将首次努力将膝关节骨关节炎患者的生物学和生物力学客观测量相关联，以个性化和改善他们的治疗和康复。这项研究的蛋白质组学方面将进一步加深我们对生物环境如何影响功能的理解，并建立在曼彻斯特大学斯托勒生物标志物发现中心的工作基础上。项目合作伙伴Medacta在为患者造福的生物医学工程方面处于领先地位，并根据3DCT计划开发了内部3D打印定制的个性化器械和植入物。学生将与Medacta的国际生物工程团队互动，学习从发明到测试、许可和商业化的过程。除了在学习期间的实习外，Medacta还为成功的学生提供为期6个月的带薪实习。

This project runs at the interface of biomedical engineering, cell biology and clinical orthopaedic surgery. It is a directly translatable project that allows the student to develop skills applicable to a variety of disciplines and also experience with patient interaction. The student will analyse the gait of patients using advanced motion capture technology, before and after knee replacement surgery and quantify knee range of motion, muscle strength, stability and gait kinematics. The student would primarily be assessing and quantifying the biomechanics of the individual patient and how the extent of disease and muscle weakness affects their movement and ability to undertake activities of daily living. The student would look specifically at the frontal plane kinematics and change in joint line and tibial inclination of the knee when the surgery is done with using personalised kinematic alignment techniques and mechanical alignment techniques. The biological milieu of the joint is important to gait and function. A proteomics approach to analysis of synovial fluid obtained at the knee replacement surgery will endeavour to correlate, for the first time, the biological and biomechanical objective measurements of patients with osteoarthritis of the knee, to personalise and improve their treatment and rehabilitation. The proteomics aspect of the study will further our understanding of how the biological environment affects function and builds on work at the Stoller Biomarker Discovery Centre, University of Manchester.The project partners Medacta are at the cutting edge of biomedical engineering for patient benefit, and have developed inhouse 3D printing of bespoke personalised instruments and implants from 3DCT planning of surgery. The student will interact with the international bioengineering team at Medacta and learn the processes of invention to testing, licensing and commercialisation. Medacta has offered the successful student a paid internship of 6 months duration at the end of their project in addition to the placements during the studentship.