Rodent Radio for Neurological Studies

描述（由申请人提供）：本项目的目的是开发一种生理无线监测设备，该设备足够小，可供小鼠或幼年大鼠佩戴。该装置将允许观察行为和测量生理参数，而不需要像传统上要求的那样拴系啮齿动物。 该计划的第一阶段开发了一种小型的双通道无线生理监测发射机，允许研究人员测量大鼠和其他小动物的EEG，EKG，EMG和其他生理参数。第一阶段开发了一种发射器，它小到足以被老鼠佩戴，并证明了这种设备的可行性。它包含数据采集部分、数字部分和可编程RF发射器部分。它被包装在一个硅浸，这将保护该设备免受尿液和其他液体以及电击。它已经在约翰霍普金斯医疗机构的老鼠身上进行了测试。 在第二阶段，发射器将缩小，使其能够用于大鼠或小鼠的发育环境。发射器将有足够的范围，以允许动物在其环境中自由移动，这将允许自由迷宫研究，甚至包括在水中导航的迷宫。在第II阶段期间，RatPaak的测试将在约翰霍普金斯继续进行，以及新开发的MousePaak的测试。

DESCRIPTION (provided by applicant): The aim of this project is to develop a physiological wireless monitoring device that is small enough to be worn by a mouse or juvenile rat. This device will allow behavior to be observed and physiological parameters to be measured without tethering the rodent as is traditionally required. The Phase I of this program developed a small, two channel wireless physiological monitor transmitter that allows EEG, EKG, EMG and other physiological parameters of rats and other small animals to be measured by researchers. The Phase I developed a transmitter, which is small enough to be worn by a rat, and demonstrated the feasibility of such a device. It contains a data acquisition section, a digital section, and a programmable RF transmitter section. It is packaged in a silicone dip, which will protect the device from urine and other fluids as well as from electric shock. It has been tested on rats at John Hopkins Medical Institutions. In Phase II, the transmitter will be shrunk to allow it to be used for developing rats or mice environments. The transmitter will have sufficient range to allow the animals to freely move about their environment, which will allow for free maze studies, and even mazes that include navigating through water. Testing on the RatPaak will be continued at Johns Hopkins during the Phase II as well as testing on the newly developed MousePaak.