Customized Electrical Stimulation for SCI Rehabilitation

描述（申请人提供）：运动可增强SCI患者的体能，并减缓SCI的继发性并发症。不幸的是，可用的锻炼设备是昂贵的，并提供边际效益。在这个第二阶段的项目中，我们将继续开发和评估一个运动系统，为SCI患者寻求改善他们的身体健康和/或使功能性电刺激系统能够用于站立。 该设备使用下肢肌肉组织的电刺激来产生耦合的髋/膝弯曲运动，该运动对抗重力移动上身。它提供了以提供下肢分级负荷的方式进行力量和耐力训练练习的能力。它由机械框架和一个多通道刺激器与自适应控制器，以产生所需的运动和GRF配置文件。 第一阶段项目通过开发一个原型，在患有SCI的人类受试者的实验中对其进行评估，并确定其局限性来证明其可行性。 设计和开发改进的设备; 2。 评估在临床环境中提供实质性运动益处的能力; 3. 运动的生物力学特性;和4。 将器械与植入式电刺激系统连接。3.表征锻炼的生物力学;以及4.将所述装置与植入的电刺激系统对接。

DESCRIPTION (provided by applicant): Exercise for people with SCI can enhance physical fitness and slow secondary complications of SCI. Unfortunately, available exercise equipment is expensive and provides marginal benefits. In this Phase II project, we will continue to develop and evaluate an exercise system for individuals with SCI seeking to improve their physical fitness and/or enable use of a functional electrical stimulation system for standing. The device uses electrical stimulation of lower-extremity musculature to generate a coupled hip/knee bending motion that moves the upper body against gravity. It provides the ability to perform strength and endurance training exercises in a manner that provides graded loading of the lower extremities. It consists of mechanical frame and a multi-channel stimulator with an adaptive controller to generate the desired movement and GRF profiles. The Phase I project demonstrated feasibility by developing a prototype, evaluating it in experiments on human subjects with SCl, and identifying its limitations.The Phase II goals are to move towards Phase Ill commercialization by:1. Designing and developing an improved device; 2. Evaluating the ability to provide substantial exercise benefits in a clinical setting; 3. Characterizing the biomechanics of the exercise; and 4. Interfacing the device with an implanted electrical stimulation system. 3. characterizing the biomechanics of the exercise; and 4. interfacing the device with an implanted electrical stimulation system.