Core--Tissue Culture Core

在协调的计划项目内进行研究的一个优势是能够创建核心设施，以（i）最有效和最经济地利用共享和共同的资源和管理需求，（ii）提供传播结果和促进小组内正在进行的研究讨论的机制，以及（iii）协调与计划外研究人员的互动，以获得关键的评估。技术咨询和智力投入，以使工作保持在轨道上，并保持在该领域的技术前沿。为此，将创建一个管理和组织培养/动物核心（核心A），并由克莉丝汀加尔博士指导。核心A将解决6个具体目标。目标1是建立组织培养/动物核心设施，以确保各种项目使用可比组织， 最经济地利用动物资源和技术支持;这将需要培训和监督海马切片培养制备技术人员，支持群体的持续培养需求和动物群体的维护。目标2是为不同的项目提供ampakine药物和共用的化学试剂（ampakine、BDNF肽和拮抗剂）;这包括从外部承包ampakine的合成。目标3是传播研究成果和协调方案项目内的合作研究活动：这将通过所有方案研究人员每月举行会议以及更频繁地举行小型合作小组会议来实现。目标4是协调与外部调查人员的互动，为项目调查人员提供审查和监督、技术建议和外部智力投入。为此正式 已成立了内部和外部咨询委员会;每个委员会都由具有与方案子项目目标有关的专门知识的杰出调查人员组成。此外，该计划将支持一系列研究研讨会，以提供新的想法和与从事相关工作的研究人员互动的场所。目标5是为集团内的计算机系统提供一般行政支持和协助。最后，目标6是确保持续遵守与材料使用、动物研究和实验室安全性相关的机构法规。

An advantage of conducting research within a coordinated Program Project is the ability to create core facilities to (i) most efficiently and economically take advantage of shared and common resource and administrative needs, (ii) provide mechanisms for disseminating results and facilitating discussions of ongoing research within the group, and (iii) coordinate interactions with investigators outside the program to obtain critical evaluation, technical advice and intellectual input to keep the work on track and at the cutting edge of technologies in the field. To this end an Administrative and Tissue Culture/Animal Core (Core A) will be created and directed by Dr. Christine Gall. Core A will address 6 specific Aims. Aim 1 is to establish Tissue Culture/Animal Core facilities to assure the various projects are using comparable tissue, and to make most the economical use of animal resources and technical support; this will entail training and oversight of technical personnel for hippocampal slice culture preparation, support for ongoing culture needs of the group and maintenance of animal colonies. Aim 2 is to provide ampakine drugs and shared chemical reagents (ampakines, BDNF peptides and antagonists) to the different projects; this includes contracting the synthesis of ampakines from outside sources. Aim 3 is to disseminate research findings and coordinate collaborative research activities within the Program Project: this will be accomplished through monthly meetings of all program investigators in addition to more frequent meetings of smaller collaborative groups. Aim 4 is to coordinate interactions with outside investigators to provide review and oversight, technical advice, and outside intellectual input to program investigators. To this end formal internal and external advisory boards have been created; each is composed of outstanding investigators with specific expertise relating to objectives of the Program Subprojects. In addition, the Program will support a series of Research Seminars to provide fresh ideas and a venue for interactions with investigators doing related work. Aim 5 is to provide general Administrative support and assistance for computer systems within the group. Finally, Aim 6 is to assure ongoing compliance with institutional regulations pertaining to material use, animal research, and laboratory safety.