Penn State Summer Symposium in Molecular Biology

描述（由申请人提供）：第22届宾夕法尼亚州立大学分子生物学夏季研讨会，题为“染色质结构和转录”的会议要求部分支持。会议将于2003年7月30日至8月2日在宾夕法尼亚州立大学公园校区的尼塔尼狮子酒店举行。在过去的十年中，人们迅速认识到染色质在真核细胞中DNA功能的各个方面的重要性。染色质在转录中的作用的两个迅速发展的方面将是这次会议的双重焦点。首先，组蛋白修饰及其逆转与基因调控有关，因为激活因子和抑制因子已被证明是或招募的，例如乙酰化酶和去乙酰化酶。同样，组蛋白甲基化、磷酸化和泛素化也由转录调控因子提供和/或识别，并作为重要的表观遗传标记发挥作用。视网膜母细胞瘤的突变可以破坏Rb与去乙酰化酶的相互作用，去乙酰化酶抑制剂在治疗某些肿瘤中显示出一定的效用。参与转录激活或抑制的其他染色质结构转变发生在大型多蛋白染色质重塑复合体的手中，其中最著名的是SWI/SNF。BRCA1与人类SWI/ snf相关复合体相关。关于组蛋白修饰和重塑的会议将涉及这些研究领域的领导者，并将补充组蛋白密码假说的创始人C. David Allis的主题演讲。其次，广泛的新技术允许对染色体背景下的远距离相互作用和核结构组织在基因组功能表达中的作用进行有意义的研究。从遗传学到光漂白后荧光恢复的方法将在结构和核组织以及远程染色体相互作用的两个平台会议上提出。这些会议将补充乌尔里希·莱姆利的全体演讲。同时举行的下午平台会议将允许36名初级研究人员向与会者介绍他们的研究；这些演讲者将从他们的海报摘要中选出。宾夕法尼亚州立大学专题讨论会的一个显著特点是靠近东海岸的大部分机构，学生的费用很低，这使得它们特别受研究生和博士后的欢迎。

DESCRIPTION (provided by applicant): Partial support is requested for the 22nd Penn State Summer Symposium in Molecular Biology, a conference entitled "Chromatin Structure and Transcription." The conference will be held July 30-August 2, 2003 at the Nittany Lion Inn on Penn State's University Park campus. The past decade has witnessed burgeoning growth in realization of the importance of chromatin in all aspects of the function of DNA in eukaryotic cells. Two rapidly developing aspects of the role of chromatin in transcription will be the dual focal points for this meeting. First, histone modifications and their reversal have been implicated in gene regulation as activators and repressors have been shown either to be or to recruit, e.g. acetylases and deacetylases, respectively. Similarly, histone methylation, phosphorylation and ubiquitination are provided and/or recognized by transcription regulators and function as important epigenetic marks. Mutations in retinoblastoma can disrupt the interaction of Rb with deacetylases and deacetylase inhibitors have shown some utility in treatment of certain tumors. Other chromatin structural transitions involved in either activation or repression of transcription occur at the hands of large multiprotein chromatin remodeling complexes, the best known of which is SWI/SNF. BRCA1 is associated with a human SWI/SNF-related complex. Sessions on histone modification and remodeling will involve leaders in these areas of research and will complement the keynote address by C. David Allis, the originator of the histone code hypothesis. Second, a broad spectrum of novel techniques is allowing meaningful study of long range interactions in the chromosome context and the role of nuclear structural organization in the functional expression of the genome. Approaches ranging from genetics to fluorescence recovery after photobleaching will be presented in two platform sessions on structure and nuclear organization and long range chromosome interactions. These sessions will complement the plenary lecture by Ulrich Laemmli. Concurrent afternoon platform sessions will allow 36 junior investigators to present their research to the conferees; these speakers will be chose from abstracts of their posters. A notable feature of the Penn State Symposia in their proximity to a large segment of East coast institutions and the low cost for students, making them particularly popular with and well attended by graduate students and post-doctoral fellows.