FASEB RESEARCH CONFERENCE: NUCLEAR STRUCTURE AND CANCER

描述(由申请人提供)：本申请是为2003年6月7日至12日在佛蒙特州萨克斯顿河的佛蒙特州学院举行的2003年FASEB夏季“核结构与癌症”研究会议提供部分资金。这次会议是由美国实验生物学学会联合会(FASE B)主办的。将举行九次定期平台会议、两次讲习班和两次海报会议。将鼓励青年研究人员从提交的摘要中挑选，在定期平台和研讨会上作简短发言。还将有一个特别的“最新发展”会议，与会者将被挑选进行简短的演讲。 本次会议将提供一个论坛，评估控制肿瘤细胞核内基因复制和表达的核酸和调控蛋白的修饰组织的基本调控和临床意义。与肿瘤相关的核形态变化和亚核组织调控因子的研究正受到越来越多的关注。考虑到这一点，有必要召开一次会议，专门研究因癌症的发生和发展而受损的细胞中间期细胞核的结构和功能特性。这是世界上唯一一次集中讨论这一具体议题的重大会议。本课程将系统地探讨核形态与基因复制和表达之间的关系。将共同努力对核组织、基因组功能和调控之间的相互作用的发现进行批判性评估。将考虑细胞、生化、遗传和分子方法的贡献，并将它们整合到多学科方法中，以了解基因组组织、功能和癌症之间的联系。为此，本次会议将讨论实验战略和高分辨率最先进的方法，以确定在癌细胞中与基因复制、表达和调节的变化有关的核结构变化。

DESCRIPTION (provided by applicant): This application is for partial funding for the 2003 FASEB Summer Research Conference on "Nuclear Structure and Cancer" to be held June 7-12, 2003 at the Vermont Academy in Saxtons River, Vermont. The conference is under the auspices of the Federation of American Societies for Experimental Biology (FASEB). There will be nine regular platform sessions, two workshops and two poster sessions. Young investigators will be encouraged to give short talks at the regular platform and workshop sessions by selection from the submitted abstracts. There will also be a special "late breaking development" session in which participants will be selected to give short talks. This conference will provide a forum to evaluate the fundamental regulatory and clinical implications of modified organization of nucleic acids and regulatory proteins that control gene replication and expression in nuclei of tumors cells. The study of tumor-related changes in nuclear morphology and the subnuclear organization of regulatory factors is gaining increased attention. With this in mind there is a need for a conference that is dedicated to examining the structural and functional properties of the interphase cell nucleus in cells that are compromised with the onset and progression of cancer. This is the only major meeting in the world that focuses on this specific topic. Correlations between nuclear morphology and gene replication and expression will be systematically explored. There will be a concerted effort to critically evaluate findings that interface between nuclear organization, genomic function and regulation. Consideration will be given to contributions from cellular, biochemical, genetic and molecular approaches and their integration into multidisciplinary approaches for understanding the connections among genomic organization, function and cancer. In so doing this meeting will address experimental strategies and high resolution state-of-the-art methodologies for defining in cancer cells alterations in nuclear architecture related to changes in gene replication, expression and regulation.