2003 Hormonal Carcinogenesis Gordon Research Conference

描述（由申请人提供）：2003年激素致癌戈登研究会议的目标是为积极参与激素致癌各个学科的新老研究人员提供一个论坛，以共同定义该领域的前沿。 主题将集中在与癌症相关的主要人类癌症如乳腺癌、子宫内膜癌、卵巢癌和前列腺癌的研究现状，包括：（1）核受体的结构/功能、受体-辅激活因子相互作用和癌症中激素激活基因的机制的研究现状;（2）激素生物合成和代谢的新进展;在癌症发生中的作用;肿瘤进展和/或癌症预防;（3）激素疗法和癌症风险;易感人群中激素诱导的癌症的遗传决定因素;（4）识别和理解细胞信号传导途径在增殖和凋亡中的作用;（5）激素致癌作用中的基因组学和蛋白质组学方法;（6）用于激素和癌症研究的适当和新型动物模型;（7）从依赖性恶性肿瘤进展到非依赖性恶性肿瘤的基本原理和事件;（8）预防和治疗肿瘤诱导的癌症的新实验和/或干预方法。 增加了新兴领域和最新主题，以帮助与会者了解该领域的新机会，海报会议将使非正式互动得以发生。 由于激素致癌作用的多学科性质，本次会议汇集了异常多样化的研究人员和参与者，包括高级，权威的研究人员以及新的研究人员和初级科学家。 其总体目标是激发新的想法，发现新的范式，分享技术进步，促进合作和互动，并认识到在这一领域的发现的历史里程碑。 会议将使与会者能够了解这一日益复杂的研究领域的最新发展，认识到最近成就的重要性，为未解决的问题设计和分享新的战略，并批判性地评估现有理论并开发新的假设。

DESCRIPTION (provided by applicant): The goal of the 2003 Hormonal Carcinogenesis Gordon Research conference is to provide a forum for established and new investigators who are actively involved in the various disciplines of hormonal carcinogenesis to come together to define the leading edges of the field. Topics will focus on current research on major hormone-related human cancers such as breast cancer, endometrial cancer, ovarian cancer and prostate cancer and will include (1) current research on the structure/function of nuclear receptors, receptor-coactivator interactions, and mechanisms of gene activation by hormones in cancers; (2) new developments in hormone biosynthesis and metabolism; roles in carcinogenesis; tumor progression, and/or prevention of cancer; (3) hormonal therapies and cancer risks; genetic determinants of hormone-induced cancers in susceptible populations; (4) identification and understanding of the role of cell signaling pathways in proliferation and apoptosis; (5) genomic and proteomic approaches in hormonal carcinogenesis; (6) appropriate and novel animal models for research in hormones and cancer; (7) basic principles and events of progression from hormone-dependent to hormone-independent malignancies; and (8) new experimental and/or interventional approaches to prevention and treatment of hormone-induced cancers. Emerging areas and late-breaking topics are added to help conferees stay abreast with new opportunities in the field, and poster sessions will enable informal interactions to occur. Because of the multi-disciplinary nature of hormonal carcinogenesis, this conference brings together an unusually diverse collection of investigators and participants, including senior, authoritative investigators as well as new investigators and junior scientists. The overall objective is to stimulate new ideas, discover novel paradigms, share technological advances, promote collaborations and interactions, and recognize historical landmarks of discoveries in this field. The conference will allow participants to be updated on the latest developments in this increasingly complex research area, to recognize the significance of recent accomplishments, to devise and share new strategies for unresolved problems, and to critically evaluate existing theories and develop new hypotheses.