Proteomics: Technologies and Applications

描述（由申请人提供） 许多原核生物和真核生物基因组序列的完成促进了新的研究方法来研究生物过程的结构、功能和控制。它们的特征在于对细胞或组织表达的特定类型的所有分子进行系统的，并且在许多情况下进行定量分析。 蛋白质的系统分析被称为“蛋白质组学”。“在最初阶段，大多数蛋白质组学工作都集中在大规模蛋白质鉴定上。 最近，蛋白质组学的目标和技术已经多样化和扩展。 目前的蛋白质组学研究试图系统地，并在适用的情况下，定量地确定蛋白质的许多特性，这些特性决定了它们的生物学功能以及不同蛋白质如何相互作用以控制和执行复杂的生物学过程。 研究的具体性质包括蛋白质丰度、修饰状态、比活性、与其他生物分子的相互作用、半衰期、亚细胞位置和结构。 当前的重大挑战包括开发合适的技术以在蛋白质组范围内确定这些特性，解释所获得的大量数据，以及将不同类型的数据整合到描述生物过程的连贯模型中。 会议的目的是汇集来自蛋白质组学研究不同领域的领先专家，讨论新兴技术及其在生物和临床研究中的应用。

DESCRIPTION (provided by applicant) The completion of the genomic sequences of a number of prokaryotic and eukaryotic species has catalyzed new research approaches to study the structure, function and control of biological processes. They are characterized by the systematic, and in many cases, quantitative analysis of all the molecules of a particular type expressed by a cell or tissue. The systematic analysis of proteins has been termed "proteomics." In an initial phase, most of the proteomics efforts were focused on large-scale protein identification. More recently, the objectives and technologies of proteomics have been diversified and expanded. Current proteomics research attempts to systematically and, where applicable, quantitatively determine the many properties of proteins that determine both their biological function and how different proteins interact to control and execute complex biological processes. Specific properties investigated include protein abundance, state of modification, specific activity, interaction with other biomolecules, half-life, subcellular location and structure. Significant current challenges include the development of suitable technologies to determine these properties on a proteome-wide scale, the interpreation of the large amounts of data obtained, and the integration of different types of data into a coherent model describing a biological process. The goal of the meeting is to bring together the leading experts from the different areas of proteomics research to discuss emerging technologies and their applications to biological and clinical research.