Insulin-like Growth Factors in Physiology and Disease

描述（由申请人提供）：戈登研究会议胰岛素样生长因子在生理学和疾病计划于2003年3月，2005年3月和2007年3月在文图拉，加州。 IGF、IGF受体和IGF结合蛋白目前是众多领域深入研究的焦点，并与多种代谢和疾病状态（包括癌症和糖尿病）有关。 会议计划将代表IGF生物学重要新研究的核心，旨在促进对IGF调节和信号传导机制感兴趣的研究人员与对IGF在癌症，发育，生理学，内分泌学和代谢中的作用感兴趣的研究人员之间的互动。 2003年的计划包括在开发和细胞转化中的IGFs的开幕演讲。 关于IGFs和癌症的快速新兴领域的几个会议将涵盖流行病学和基本机制，重点是乳腺癌和前列腺癌。 其他会议包括IGF信号和胰岛素信号的相似性/差异，IGFs在代谢疾病中的作用，IGFs和受体的分子生物学，IGFBPs及其蛋白酶的作用，以及IGFs在特定组织中的功能，包括骨骼和生殖组织。 会议的闭幕式将集中在非常新的，令人兴奋的话题胰岛素/IGF信号在寿命和衰老的调节。 计划于2005年和2007年举行的后续会议将侧重于关键细胞和疾病过程中IGF信号和调节的当前发展。 这些会议的一个重要优势是IGFs的生物学对许多学科的研究人员都很感兴趣。 IGF戈登研究会议将是促进对IGF生物学感兴趣的研究人员与对致癌和代谢紊乱感兴趣的研究人员之间互动的关键机制。 这种相互作用对于理解IGF配体、受体和结合蛋白的不同功能和调节及其在正常组织功能和疾病中的作用的快速进展至关重要。

DESCRIPTION (provided by applicant): Gordon Research Conferences on Insulin-like Growth Factors in Physiology & Disease are planned for March 2003, March 2005 and March 2007 in Ventura, California. The IGFs, IGF receptors and the IGF binding proteins currently are the focus of intense investigation across numerous fields and have been implicated in several metabolic and disease states including cancer and diabetes. The conference programs will represent the core of important new research in IGF biology and will be designed to foster interactions between investigators interested in mechanisms of IGF regulation and signaling and those interested in the IGFs in cancer, development, physiology, endocrinology and metabolism. The program for 2003 includes opening presentations on the IGFs in development and in cell transformation. Several sessions on the rapidly emerging area of IGFs and cancer will cover epidemiology and basic mechanisms with a focus on breast and prostate cancer. Other sessions include IGF signaling and the similarities/differences with insulin signaling, the role of IGFs in metabolic diseases, the molecular biology of the IGFs and receptors, the actions of the IGFBPs and their proteases, and the function of IGFs in specific tissues including bone and reproductive tissues. The closing session of the conference will focus on the very new, exciting topic of insulin/IGF signaling in the regulation of life-span and aging. Subsequent meetings that are planned for 2005 and 2007 will focus on current developments in IGF signaling and regulation in critical cellular and disease processes. A significant strength of these conferences is that the biology of the IGFs is of interest to investigators across numerous disciplines. The IGF Gordon Research Conference will be a critical mechanism to promote interaction between investigators interested in IGF biology and those interested in carcinogenesis and metabolic disorders. Such interactions will be essential for rapid progress in understanding the diverse functions and regulation of the IGF ligands, receptors and binding proteins an their roles in normal tissue function and in disease.