Gordon Conference, Salivary Glands & Exocrine Secretion

描述（由申请人提供）：本申请寻求对将于2003年2月2日至7日在加州文图拉的假日酒店举行的第四届戈登唾液腺和外分泌研究会议的支持。会议将提供一个论坛，介绍和广泛讨论在了解唾液腺和相关外分泌腺的发育，功能和功能障碍的分子基础方面的最新进展。本次会议的总主题是上皮细胞和腺组织的发育和极化功能。个别会议将突出关于上皮极性起源的分子和细胞相互作用的新见解;腺体形态发生和维持;蛋白质，液体和电解质分泌;涉及上皮的疾病中的运输功能障碍;细胞内信号传导和极化膜运输的空间组织;和临床观察到的腺体功能障碍。在可能的范围内，会议将整合哺乳动物和无脊椎动物的实验系统，利用各自的简易遗传和生化/生理方法对进化保守的事件和功能的共同理解。主题演讲将以国际知名的研究人员为特色，他们涵盖上皮极性发展领域的一般主题，干燥综合征（Michael Humphreys-Beher纪念馆）的基本基础，以及功能基因组学，蛋白质组学和信号网络在探索腺体发育和细胞功能中的应用。 在组织这次会议时，确定了广泛的国家和国际发言人，特别强调有前途的年轻和新成立的研究人员，他们的研究涉及或明显影响对唾液腺和其他外分泌腺的发育和功能的理解。组织团队的目标是鼓励这一重要领域的发展和丰富，并激发研究唾液腺的新策略。

DESCRIPTION (provided by applicant): This application seeks support for the fourth Gordon Research Conference on Salivary Glands and Exocrine Secretion to be held February 2-7, 2003 at the Holiday Inn in Ventura, California. The conference will provide a forum for presentation and extensive discussion of the most recent progress in understanding the molecular basis of development, function and dysfunction of salivary and related exocrine glands. The general theme of this conference is on the development and polarized function of epithelial cells and glandular tissues. Individual sessions will highlight new insights concerning molecular and cellular interactions underlying the origin of epithelial polarity; glandular morphogenesis and maintenance; protein, fluid and electrolyte secretion; transport dysfunction in diseases involving epithelia; spatial organization of intracellular signaling and polarized membrane trafficking; and clinically observed glandular dysfunction. To the extent possible, sessions will integrate mammalian and invertebrate experimental systems to capitalize on the respective facile genetic and biochemical/physiological approaches toward the common understanding of evolutionarily conserved events and functions. Keynote addresses will feature established investigators of international stature who encompass the general theme in the areas of development of epithelial polarity, the fundamental basis of Sjogren's Syndrome (a Michael Humphreys-Beher memorial), and the application of functional genomics, proteomics and signaling networks in exploring glandular development and cellular function. In organizing this conference, a broad range of national and international speakers has been identified with special emphasis on promising young and newly established investigators whose research either addresses or clearly impacts on the understanding of the development and function of salivary and other exocrine glands. It is the goal of the organizing team to encourage both growth and enrichment of this important field and to stimulate new strategies for studying salivary glands.