CONFERENCE: 'Toward Understanding Islet Biology'

描述(由申请人提供)： 糖尿病是一种代谢性疾病，迅速发展成为对人类健康的主要威胁之一，目前全球估计有1.5亿例糖尿病病例。尽管基础科学家和临床研究人员在糖尿病研究方面取得了快速进展，但主要侧重于激素作用和胰岛素抵抗领域。在过去的几年里，胰岛在I型和II型糖尿病的发展中起着重要的作用，已经成为一个中心角色。最近在胰岛生物学方面取得的快速、广泛的进展远远超过了目前以糖尿病或内分泌学等为重点的大型大会所提供的科学陈述、辩论和讨论的机会。为了满足这一需要，我们组织了一次专门讨论胰岛生物学的Keystone研讨会会议。本申请申请资助学员参加首届小岛生物基石研讨会。该计划旨在突出、整合和捕捉胰岛生物学在多个领域取得的科学进展，包括但不限于：β细胞分化、生长、再生和死亡；转录因子和胰岛基因表达；胰岛素合成、转化、运输和颗粒生物发生；刺激-分泌耦合；以及1型糖尿病的遗传学和移植。预防糖尿病和控制其并发症将需要一种综合的国际方法。我们组织这次研讨会的目的是将来自传统上没有机会互动的学科的临床医生和基础研究人员的国际小组聚集在一起。我们的目标是促进必要的思想交流，以继续推进胰岛生物学的进步，并招募有才华的年轻科学家到该领域。来自学术界和产业界的知名研究人员、教职员工、研究生和医学生以及博士后实习生将出席本次会议。将特别重视招募年轻受训人员，并利用这笔旅费补贴抵消他们的费用，此外，还特别努力在整个会议期间吸纳妇女和少数族裔。

DESCRIPTION (provided by applicant): Diabetes is a metabolic disorder rapidly developing into one of the main threats to human health with a currently estimated figure of 150 million cases globally. Although there has been rapid progress in diabetes research by both basic scientists and clinical investigators the major emphasis and progress has been in the areas of hormone action and insulin resistance. Over the last several years the pancreatic islet has emerged as a central player with a major role in the development of type I and type II diabetes. Recent rapid, broad advances in islet biology have far outstripped the opportunities for scientific presentation, debate and discussion currently provided by large general meetings focused, for example, on Diabetes or Endocrinology. To address this need we have organized a Keystone Symposium Conference devoted entirely to islet biology. This application requests funds to support trainees to attend this first Islet Biology Keystone Symposium. The program is designed to highlight, integrate and capture the scientific progress occurring in islet biology in multiple areas including, but not limited to: Beta Cell Differentiation, Growth, Regeneration and Death; Transcription Factors and Gene Expression in Islets; Insulin Synthesis, Conversion, Trafficking and Granule Biogenesis; Stimulus-Secretion Coupling; and Genetics and Transplantation for type 1 diabetes. The prevention of diabetes and control of its complications will require an integrated, international approach. We have organized this Symposium with the intention of bringing together an international group of clinicians and basic researchers from disciplines that traditionally have not had an opportunity to interact. Our goal is to promote the cross-fertilization of ideas necessary to continue the advance of islet biology and recruit talented young scientists to the field. Well known researchers, faculty, graduate and medical students, and post-doctoral trainees from academia and industry will be represented at this conference. Special emphasis will be placed on recruiting young trainees and offsetting their costs with the help of this travel grant, in addition, particular efforts have been made to include women and ethnic minorities throughout the meeting.