Respiratory Triggers and Sensory Irritation: Role of Environmental Pollution in Respiratory Symptoms

探讨环境污染物对感觉神经的影响及其在呼吸道症状(炎症反应/咳嗽/支气管痉挛)发生或加重中的作用。我们将研究Trp通道激活在这些事件中的作用(首先是我们小组和其他人确定的那些在呼吸道传入如TRPV1、TRPA1、TRPV4、TRPM3、TRPM8上的激活)。为了研究这些机制，我们将使用一系列技术，包括体内和体外电生理学、新型体外细胞和组织模型、最先进的细胞成像和动物模型系统。深入了解环境对这种生物过程的影响背后的机制可以揭示新的治疗策略，同时强调环境中存在的各种产品不需要的特征。

To investigate the effects of environmental pollutants on sensory nerves and the subsequent role in the initiation or exacerbation of respiratory symptoms (inflammatory responses/cough/bronchospasm). The contribution of TRP channel activation (starting with those identified by our group and others on airway afferents e.g. TRPV1, TRPA1, TRPV4, TRPM3, TRPM8) in these events will be studied. To investigate these mechanisms, we will be using a range of techniques including in vivo and in vitro electrophysiology, novel ex vivo cell and tissue models, state-of-the-art cellular imaging and animal model systems. Insight into the mechanisms behind environmental influences on such biological process could reveal novel therapeutic strategies, whilst highlighting unwanted features of various products present in the environment.