EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT CONSTRUCTION

描述（由申请人提供）： 该提案要求400万美元的NCRR资金，以完成34，018平方米。英尺动物的住房，程序，和支持空间。 当与伯明翰亚拉巴马大学（UAB）的625万美元相匹配时，该奖项将在研究支持大楼（RSB）的五层楼中装修两层。 RSB将作为UAB动物支持中心之一，建设即将开始。 该奖项将用于完成和装备17，009平方米。英尺1级动物饲养空间（笼清洗、高压灭菌、接收、尸检、储存），5级动物饲养和手术空间等量。 第5层设计为ABSL-2，但面积为1，835平方米。英尺ABSL-3/BSL 3生物防护套件。 该项目将为超过8000个小型老鼠笼提供通风的空间。 该空间将主要用于圈养UAB免疫学和自身免疫计划的研究人员的动物，该计划拥有超过7500万美元的积极和待定的PHS资金。 此外，该项目还将缓解校园范围内因每日老鼠普查每年增加14%而对动物空间造成的压力。 它还支持四个小鼠核心设施，为许多PHS研究人员提供服务（gnotobiotics，杂交瘤/噬菌体展示，复杂性状的映射和遗传工程小鼠的繁殖）。 最后，该项目致力于实现我们的长期目标，即集中动物护理和程序空间，以便以最低的成本优化动物项目的质量。

DESCRIPTION (provided by applicant): This proposal request $4 million NCRR funding to complete 34,018 sq. ft. of animal housing, procedure, and support space. When matched with $6.25 million from the University of Alabama at Birmingham (UAB) this award will fit-out two of five floors in the Research Support Building (RSB). The RSB will serve as one of to UAB hubs for animal support, and construction is about to begin. The award will be used to finish and equip 17,009 sq. ft. of animal support space (cage wash, autoclave, receiving, necropsy, storage) on Level 1 and an equal amount of animal housing and procedure space on Level 5. Level 5 is designed at ABSL-2 but has 1, 835 sq. ft. ABSL-3/BSL3 biocontainment suite. The project will provide space for over 8, 000 small mouse cages in ventilated racks. The space will be used primarily to cage the animals of investigators in the UAB Immunology and Autoimmunity Program, a program with over $75 million in active and pending PHS funding. In addition, the project will relieve the campus-wide pressure on animal space caused by the ongoing 14 percent annual increase in the daily mouse census. It also supports four mouse core facilities servicing many of these PHS investigators (gnotobiotics, hybridoma/phage display, mapping of complex traits, and propagation of genetically engineered mice). Lastly, this project works toward our long-term goal of centralizing animal care and procedure space so as to optimize the quality of the animal program at minimal costs to investigators and research sponsors.