Construction/SEBLAB/Regional Biocontainment Laboratory

描述（由申请人提供）：位于伯明翰的亚拉巴马大学（UAB）建议在其校园内建造亚拉巴马伯明翰东南生物防护实验室（SEBLAB）。这个41，060 gsf的区域生物防护实验室（RBL）将需要1590万美元的NIAID资金与UAB的530万美元相匹配。UAB是领导东南地区新兴感染和生物防御卓越中心的六个机构之一，该中心是八个州第四区生物防御工作的重点。UAB是RBL的杰出选择，原因有几个。其中包括UAB的附属机构南方研究所的经验和补充生物防御能力，UAB备灾中心在生物防御规划和培训方面发挥的国家领导作用，以及特殊的核心设施。最重要的是，UAB研究人员在病毒学，细菌发病机制，免疫学和疫苗开发方面有杰出的记录。这些研究人员中的许多人，以及新招募的人员，现在正在利用他们的技能来解决与生物防御和新出现的感染直接相关的问题，重点关注NIAID的优先病原体。这一努力现在受到UAB校园内生物防护空间可用性的限制。SEBLAB将极大地促进国家从这一人才中获得最大利益，并将为来自其他机构的访问研究人员提供一个丰富的环境，这些研究人员正在进行需要生物遏制的研究。SEBLAB的设计包括灵活和安全的BSL-2和3实验室，ABSL-3住房和程序空间以及办公室。在发生生物恐怖主义紧急情况时，SEBLAB将提供快速反应能力，进行诊断和其他必要的分析，以加强国家和区域的公共卫生反应。

DESCRIPTION (provided by applicant): The University of Alabama at Birmingham (UAB) proposes to construct on its campus the Southeast Biocontainment Laboratory Alabama Birmingham (SEBLAB). This 41,060 gsf Regional Biocontainment Laboratory (RBL) will require $15.9 million of NIAID funding to be matched with $5.3 million from UAB. UAB is one of six institutions leading the Southeastern Regional Center for Excellence in Emerging Infections and Biodefense, the focus of biodefense efforts for the eight-state Region IV. UAB is an outstanding choice for an RBL for several reasons. These include the experience and complementary biodefense capabilities of UAB's affiliate, Southern Research Institute, the national leadership role that the UAB Center for Disaster Preparedness has taken in biodefense planning and training, and exceptional core facilities. Most importantly, UAB investigators have distinguished records in virology, bacterial pathogenesis, immunology, and vaccine development. Many of these investigators, as well as new recruits, are now bringing their skills to bear on issues directly relevant to biodefense and emerging infections, concentrating on NIAID priority pathogens. This effort is now limited by the availability of biocontainment space on the UAB campus. SEBLAB will greatly facilitate maximal national benefit from this talent, and will provide a rich environment for visiting researchers from other institutions doing research that requires biocontainment. SEBLAB's design includes flexible and secure BSL-2 and 3 laboratories, ABSL-3 housing and procedure space, and offices. In the event of a bioterrorism emergency, SEBLAB will provide surge capacity for diagnostics and other necessary analyses to enhance state and regional public health responses.