Evolutionary pressures on cell types: leveraging species differences to gain insight into neurodegenerative disease risk

目标1：利用全基因组证据识别细胞类型，这些证据表明它们在哺乳动物进化的关键步骤中受到蛋白质编码序列上的选择压力的影响目的2：表征选择对调节区域的影响并识别受影响的细胞类型目的3：绘制来自人类死后脑组织的细胞类型群体中的组蛋白修饰，并使用这些来训练细胞类型特异性调节因子的模型目的4：识别与特定细胞类型的选择压力相关的表型

Aim 1: Identifying cell types with genome-wide evidence that they are affected by selective pressures on protein coding sequences at key steps in mammalian evolution Aim 2: Characterise effect of selection on regulatory regions and identify the affected cell types Aim 3: Map histone modifications in populations of cell types from human post-mortem brain tissue and use these to train the model on cell type-specific regulatory factors Aim 4: Identify phenotypes associated with selection pressures on particular cell types