Investigating selection and co-selection for antimicrobial resistance by non-antibiotic drugs and plant protection products

越来越多的研究表明，低浓度的抗生素可以选择抗微生物药物耐药性。第一篇显示非抗生素药物（NADs）可以在人类肠道相关菌株中选择抗微生物药物耐药性（AMR）的论文刚刚发表，这引起了人们对体内AMR选择的关注。nad也存在于废水处理厂，与抗生素和其他抗微生物化合物一起作为微污染物存在。这种潜在选择性污染物的混合物将存在于污水污泥中，与植物保护产品（PPP）一起作为肥料应用于农业土壤。这些多重压力如何相互作用以选择陆地环境中的抗菌素耐药性，以及它们如何影响微生物多样性是一个全新的研究领域，有可能影响国际层面的政策，为可持续农业实践提供信息，并提高对抗菌素耐药性进化和微生物生态学的基本理解。

A growing body of research has demonstrated low concentrations of antibiotics can select for antimicrobial resistance. The first paper showing non-antibiotic drugs (NADs) can select for antimicrobial resistance (AMR) in human gut-associated strains has just been published, raising concerns for selection for AMR in vivo. NADs are also present in waste water treatment plants, alongside antibiotics and other antimicrobial compounds where they are present as micropollutants. This cocktail of potentially selective contaminants will be present in sewage sludge, which is applied to agricultural soils as a fertiliser alongside plant protection products (PPP). How these multiple pressures may interact to select for AMR in terrestrial environments and how they impact microbial diversity is a completely novel research area, with the potential to influence policy at an international level, inform sustainable agricultural practices, and improve fundamental understanding of AMR evolution and microbial ecology.