Experimental Mechanistic Studies of Catalytic Reactions

该项目的目的是使用通过现代机械方法学获得的知识来改进催化系统。为了收集机械研究的数据，我们将使用现代反应监测工具，如流动探针NMR，ReactIR和使用自动进样器。所获得的数据将通过基于对整个反应概况的检查的动力学分析进行分析，例如最近开发的可变时间归一化分析（VTNA）。通过机理研究获得的信息将用于在周转频率、周转次数和所需起始材料的减少方面改进化学反应。我们设想，一些改进将需要在一种或多种反应组分（底物、催化剂或添加剂）的反应过程期间的受控添加曲线。与该项目相关的EPSRC研究领域：催化，合成有机化学，化学反应动力学和机理，控制工程。物理科学和制造业的未来研究主题。

The aim of the project is to improve catalytic systems using the knowledge obtained through modern mechanistic methodologies.To collect the data for the mechanistic studies we will use modern reaction monitoring tools, such as the flow probe NMR, ReactIR and the use of autosamplers. The data obtained will be analysed by kinetic analyses based on the examination of entire reaction profiles, such as the recently developed Variable Time Normalization Analysis (VTNA).The information through the mechanistic studies will be used to improve the chemical reactions in terms of turnover frequencies, turnover numbers and reduction of starting material required. We envision that some of the improvements will require a controlled addition profile during the course of the reaction of one or more reaction components: substrates, catalyst or additives. Relevant EPSRC research areas to the project: Catalysis, Synthetic Organic Chemistry, Chemical Reaction Dynamics and Mechanisms, Control Engineering. Research Themes of Physical Sciences and Manufacturing the future.