Spectro-temporal and binaural response properties

描述（由申请人提供）：下丘中央核（ICC）在频谱、时间和双耳信息的声学分析中起关键作用。它的层状组织和高度有序的马赛克会聚传入表明巩固听觉信息的过渡到听觉丘脑的关键作用。我们假设，频谱时间和双耳感受野功能的分布布局将系统地在中央核的方式，反映了支配传入和局部丘电路的模式。在这项研究中，我们提出了中央核团内的光谱-时间感受野（STRF）偏好的分布组织的特征。结构化宽带噪声的STRF分析将被用来表征神经元的偏好，并系统地将这些与传统的纯音刺激测量。单单位记录实验的特点，STRF的喜好，并确定在从脑干到中央核的转换感受野遗传/建设的作用的微观组织。分布式映射的ICC将使我们能够同时表征的三维结构内的频谱，时间和双耳感受野偏好的全球组织。同步解剖学研究将显示两个平行记录轨道的地形位置和它们各自的投影到内侧膝状体。预期的研究结果将提供一个框架，用于理解在复杂的听觉刺激，然后我们可以与脑干输入，本地电路和模块化组织的组织层次结构的频谱时间和双耳功能的声学分析。

DESCRIPTION (provided by applicant): The central nucleus of the inferior colliculus (ICC) plays a key role in the acoustic analysis of spectral, temporal and binaural information. Its laminar organization and highly ordered mosaic of converging afferents suggests a critical role in consolidating this acoustic information in the transition to the auditory thalamus. We hypothesize that the distributed layout of spectro-temporal and binaural receptive field features will be systematically ordered in the central nucleus in a manner that reflects the patterns of innervating afferents and the local collicular circuitry. In this study, we propose to characterize the distributed organization of spectro-temporal receptive field (STRF) preferences within the central nucleus. STRF analysis with structured broadband noise will be used to characterize neuronal preferences and to systematically relate these to measurements from conventional pure-tone stimuli. Single unit recording experiments are proposed to characterize the micro-organization of STRF preferences and to identify the roles of receptive field inheritance / construction in the transformation from the brainstem to the central nucleus. Distributed mapping of the ICC will then allow us to simultaneously characterize the global-organization of spectral, temporal and binaural receptive field preferences within the three dimensional structure. Concurrent anatomic studies will show the topographic position of two parallel recording tracks and their respective projections to medial geniculate body. The expected findings will provide a framework for understanding the acoustic analysis of spectro-temporal and binaural features in complex auditory stimuli, which we can then relate to the organizational hierarchy of brainstem inputs, local circuitry, and modular organization.