Transportable Chlorine Dioxide Sterilization System

描述(由申请人提供)： 在美国，医疗感染仍然是发病率和死亡率的主要原因。拟议的研究的主要目标是开发一种可移动的消毒柜，用于医院、诊所、医生办公室和辅助生活环境等患者护理设施中。将使用二氧化氯气体作为灭菌剂。该计划的一个主要方法目标是开发一种与可移动柜一起使用的一次性二氧化氯产生系统。拟议系统的一个主要优势是使用二氧化氯气体，它具有杀死包括细菌、病毒、霉菌和真菌在内的各种微生物的既定能力。已经制定了三个具体目标来评估该灭菌装置的可行性。 具体目标1.将评估提供杀孢子活性所需的最佳二氧化氯浓度和处理时间。 具体目的2.评价二氧化氯灭菌对医疗器械材料性能的影响。 具体目标3.将使用可重复使用的医疗器械作为测试系统来评估商用灭菌装置和一次性气体产生系统的原型的效果。在这些研究完成后，将寻求第二阶段资金，以优化可移动绝育装置并使其商业化。

DESCRIPTION (provided by applicant): Medical infections remain a major cause of morbidity and mortality in the United States. The proposed studies have a primary goal to develop a transportable sterilization cabinet for use in patient care facilities including hospital, clinics, physician offices and assisted living environments. Chlorine dioxide gas will be used as the sterilizing agent. A major methodological goal of this program is the development of a disposable chlorine dioxide generating system to be used with the transportable cabinet. A major advantage of the proposed system is the use of chlorine dioxide gas with its established ability to kill a wide range of microbes including bacteria, viruses, mold and fungi. Three specific aims have been developed to evaluate the feasibility of this sterilization unit. Specific Aim 1. will evaluate optimal concentrations of chlorine dioxide and treatment times necessary to provide sporicidal activity. Specific Aim 2. will evaluate the effect of CIO2 sterilization on medical instrument material characteristics. Specific Aim 3. will evaluate the efficacy of a prototype commercial sterilization unit and disposable gas generation system using reusable medical instruments as a test system. Following completion of these studies Phase II funding will be sought to optimize and commercialize a transportable sterilization unit.