BIOACTIVE-ABSORBABLE COIL FOR BRAIN ANEURYSM THERAPY

描述（由申请人提供）：电解可解脱弹簧圈（GDC）是脑动脉瘤血管内治疗的金标准。然而，GDC在宽颈动脉瘤（> 4 mm）中似乎不太有效。我们建议开发一种新的生物活性、生物可吸收聚合材料（BPM）弹簧圈，通过加速动脉瘤内的凝块成熟和组织化来改善动脉瘤愈合。我们假设动脉瘤愈合可以通过使用BPM来控制。 长期目标：通过克服GDC系统目前的局限性，提高脑动脉瘤的临床治疗水平。引发动脉瘤愈合的生物分子级联的知识将允许其操作和更好的栓塞剂的开发。 直接目的：1）手术创建的动脉瘤中自然血栓形成的生物分子和组织学评价。将特别关注与凝块成熟相关的细胞因子表达。2)用于脑动脉瘤治疗的市售聚合物的物理、化学和降解特性的体外评价。3)利用猪侧动脉瘤模型评价市售聚合物不同生物吸收特性的解剖学和组织学效应及其对动脉瘤愈合的影响。4)将当前GDC技术转换为生物活性表面GDC（混合BPM/GDC），并评价混合BPWGDC线圈的血管造影和组织学有效性。5)用于颅内动脉瘤血管内栓塞的100%生物相容性活性血管内弹簧圈的开发

DESCRIPTION (provided by applicant): Guglielmi detachable coils (GDCs) are the gold standard for endovascular treatment of brain aneurysms. However, GDCs appear to be less effective in wide-necked aneurysms (> 4mm). We propose to develop a new, bio-active, bio-absorbable polymeric material (BPM) coil that improves aneurysm healing by accelerating clot maturation and organization within the aneurysm. We hypothesize that aneurysm healing can be controlled by using BPMs. LONG-TERM OBJECTIVE: To improve clinical management of brain aneurysms by overcoming the present limitations of GDC system. The knowledge of the bio-molecular cascade eliciting aneurysm healing will allow its manipulation and development of better embolic agents. IMMEDIATE OBJECTIVE: 1) Bio-molecular and histological evaluations of natural thrombus formation in surgically created aneurysm. Special attention will be paid on cytokine expression related to clot maturation. 2) In-vitro evaluation of physical, chemical and degradation properties of commercially available Polymers for potential application in brain aneurysm therapy. 3) Utilization of a lateral aneurysm model in swine to evaluate anatomical and histological effects of different bioabsorption properties of commercially available Polymers and their impact in aneurysm healing. 4) Transform current GDC technology to bioactive surface GDC (Hybrid BPM/GDC) and evaluation of angiographic and histological effectiveness of a Hybrid BPWGDC coil. 5) Development of a 100 percent bio-absorbablehio-active intravascular coil for endovascular embolization of intracranial aneurysms