SPORE IN BREAST CANCER

这项关于约翰霍普金斯大学医疗机构乳腺癌卓越研究(孢子)专门计划的提案汇集了一个高度互动的、多学科的乳腺癌转化研究计划。该孢子包括四个研究项目和七个综合项目，涵盖风险评估、诊断、分期、治疗和预防等领域。计划1，开发分子标记以确定乳腺癌的进展和分类。项目1A，乳腺癌的分子标记(Saraswati Sukumar Ph.D.)，项目1B，乳腺癌的分子表型(Edward Gabrielson M.D.)。项目2项目2A，乳腺癌的分子检测(James Herman医学博士)。项目3，乳腺癌治疗和预防的分子策略的发展。项目3A，用于乳腺癌治疗的新型多胺类似物(Robert Casero博士)；项目3B，使用去甲基化和组蛋白去乙酰化剂治疗乳腺癌(Nancy Davidson药物治疗乳腺癌)(Nancy Davidson医学博士)；项目3C，疫苗：乳腺癌预防的新范例(伊丽莎白·贾菲，医学博士)。方案4项目4A，乳腺癌进展的分子流行病学(凯西·赫尔苏尔医学博士，MHC)。这七个研究项目得到了三个核心的支持：核心1、行政和通信(医学博士南希·戴维森)。核心2，人类标本资源和数据库(Mark Sherman M.D.)促进对转化型乳腺癌研究感兴趣的个人的职业发展。

This proposal for a Specialized Program of Research Excellence (SPORE) in Breast Cancer at The Johns Hopkins Medical Institutions brings together a highly interactive, multi-disciplinary program of translational research in breast cancer. The SPORE includes four research programs with seven integrated projects spanning the fields of risk assessment, diagnosis, staging, treatment, and prevention. Program 1, Development of molecular markers to define breast cancer progression and classification. Project 1A, Molecular markers for breast cancer (Saraswati Sukumar Ph.D.), Project 1B, Molecular phenotypes of breast cancer (Edward Gabrielson M.D.). Program 2 Project 2A, Molecular detection of breast cancer (James Herman M.D.). Program 3, Development of molecular strategies for breast cancer therapy and prevention. Project 3A, Novel polyamine analogs for breast cancer treatment (Robert Casero Ph.D.); Project 3B, Use of demethylating and histone deacetylating agents to treat breast cancer (Nancy Davidson agents to treat breast cancer (Nancy Davidson, M.D.); Project 3C, Vaccines: A new paradigm for breast cancer prevention (Elizabeth Jaffee, M.D.). Program 4 Project 4A, Molecular epidemiology of progression to breast cancer (Kathy Helzlsour M.D., MHC). These seven research projects are supported by three cores: Core 1, Administration and communications (Nancy Davidson, M.D.). Core 2, Human specimen resource and database (Mark Sherman M.D.) To facilitate career development of individuals with an interest in translational breast cancer research.