Enhancing the benefits and effectiveness of Novamin for dentine hypersensitivity and remineralisation of dental tissues

大约30%的人患有牙齿过敏。这个问题是由于牙釉质丢失或牙本质小管暴露于口腔环境而引起的。治疗是可能的，通过使用含有活性成分的牙膏，封闭牙本质小管，防止刺激转移到牙齿的神经。这些活性成分还在任何暴露的牙本质上提供保护层，并提供一系列可以提高组织矿化水平的元素。与葛兰素史克公司合作，博士将研究提高上述三种有益效果的方法，他们目前的敏感性处理牙膏配方。候选人将有机会接受培训，在项目期间使用一系列表征和成像技术。该项目将使用纳米机械和纳米摩擦学测试来确定和比较牙膏形成的不同保护层，以及许多材料表征技术来确定影响保护层性能的变量。此外，该项目将使用一系列成像技术，包括串行块面扫描电子显微镜，以观察小管闭塞程度和有效成分进入小管的渗透程度，以及由于处理而导致的矿化程度变化。透射电子显微镜也将用于识别影响矿化变化的关键因素以及它们如何与组织结合。

Tooth hypersensitivity affects around 30% of the population. This issue originates due to enamel loss or gun recession and the exposure of dentine tubules to the oral environment. Treatment is possible through the use of toothpastes containing active ingredients which occlude the dentine tubules preventing the transfer of stimuli to the nerves of the tooth. These active ingredients also provide a protective layer over any exposed dentin and provide a range of elements which can enhance the level of mineralisation of the tissue. In partnership with GlaxoSmithKline, the PhD will investigate methods of enhancing the three afore mentioned beneficial effects of their current sensitivity treating toothpaste formulation. The candidate will have the opportunity to be trained to use a range of characterisation and imaging techniques during the project.The project will use nanomechanical and nanotribological testing to determine and compare the different protective layers formed by the toothpastes as well as a number of material characterisation techniques to identify the variables affecting the layers performance. In addition the project will use a range of imaging techniques including Serial block face scanning electron microscopy to look at the level of tubule occlusion and penetration of the active ingredients into the tubules, as well as the level of mineralisation change due to the treatment. Transmission electron microscopy, will also be used to identify the key elements effecting the mineralisation change and how they have integrated with the tissue.