Implementation and Implications of Sickle Cell Trait Screening in the NCAA

摘要 2010年，全国大学生体育协会(NCAA)通过了一项强制性的镰状细胞特征(SCT) I级(DI)学院和大学对学生运动员的筛选政策。目前，所有的学校 NCAA的三个部门正在实施这项政策。到目前为止，发表的研究成果很少。 关于学生运动员SCT或NCAA筛查政策的实际执行情况。许多重要的 关于这一有争议的强制基因筛查计划，问题仍然存在。因此，有必要 更好地了解该政策的挑战、限制和风险，并制定应对这些挑战、限制和风险的战略。 我们的资助基金(R01HG010364-01A1)有两个目标：1)评估实施情况、风险和次要因素 NCAA SCT筛查政策的好处，并确定贡献者和变异的影响 这些领域使用混合方法方法和2)提供关于当前NCAA SCT政策的指导和 实践和其他类似的公共卫生政策和实践。目前，我们已经完成了数据采集 并正在进行数据分析，以实现目标1。更好地解释结果并制定战略，以 为了应对政策中的挑战，我们将召开一次有精选研究人员参加的全国峰会， 机构和政策层面的实践者和决策者。峰会与会者将审查调查结果 从目标1开始，检查来自NCAA和NATA的现有SCT管理指南，协作开发 根据需要对现行程序提出修改建议，并确定和传播最佳 未来实施NCAA SCT政策的做法。把我们的研究放在政策的基础上 实施文献还将使我们能够考虑我们的发现如何为其他以人口为基础的 基因筛查工作。 这一补编将促进国家首脑会议(目标2)的规划和执行，并推动 目标1成果的解释、应用、翻译和传播。具体而言， 峰会将提供一个独特的机会，分享有关程序的前所未有的信息， 不同的专家组对NCAA政策的看法和结果。它还将启用关键 检查NCAA政策和其他公共卫生的实际和预期的好处、风险和有效性 遗传政策，并加快努力解决令人关切的领域。总体而言，该项目将建立一个有用的 NCAA政策及类似政策未来执行决策的经验基础 旨在预防疾病和保护公众健康的政策和方案。

ABSTRACT In 2010 the National Collegiate Athletic Association (NCAA) adopted a mandatory sickle cell trait (SCT) screening policy for student-athletes in its Division I (DI) colleges and universities. Currently, schools in all three divisions of the NCAA are implementing the policy. To date, very little published research is available on SCT in student-athletes or on the actual implementation of the NCAA screening policy. Many important questions remain regarding this controversial mandated genetic screening program. Therefore, it is necessary to better understand the policy's challenges, limitations, and risks, and to develop strategies to address them. Our funded grant (R01HG010364-01A1) has two aims: 1) assess implementation, risks, and secondary benefits of the NCAA SCT screening policy and determine contributors and implications of variation within these domains using a mixed methods approach and 2) provide guidance on the current NCAA SCT policy and practice and other similar public health policies and practices. Currently, we have completed data collection and are working on data analysis to address Aim 1. To better interpret the results and develop strategies to address the challenges in the policy, we will convene a national summit involving selected researchers, practitioners, and decision-makers at institutional and policy levels. Summit participants will review the findings from Aim 1, examine existing SCT management guidelines from the NCAA and NATA, collaboratively develop recommendations for modifications to current procedures as needed, and identify and disseminate best practices for future implementation of the NCAA SCT policy. Grounding of our research in the policy implementation literature will also allow us to consider how our findings can inform other population-based genetic screening efforts. This supplement will facilitate the planning and execution of the national summit (Aim 2) and advance the interpretation, application, translation, and dissemination of the results from Aim 1. Specifically, the summit will provide a unique opportunity to share unprecedented information about the procedures, perceptions, and outcomes of the NCAA policy with a diverse group of experts. It will also enable critical examination of real and perceived benefits, risks, and effectiveness of the NCAA policy and other public health genetics policies, and expedite efforts to address areas of concern. Overall, the project will establish a useful empirical foundation for decision-making concerning future implementation of the NCAA policy and similar policies and programs aimed at preventing illness and protecting the public's health.