Multi-wavelength high-density diffuse optical tomography: development, validation and clinical applications

我们的跨学科研究实验室NeoLAB位于剑桥的Evelyn围产期成像中心（EPIC），包括来自UCL和剑桥的研究人员。NeoLAB率先开发了新型光子成像系统和方法，并将其应用于新生儿大脑的研究。与UCL分拆的Gowerlabs Ltd合作，我们目前正在开发完全可穿戴的近红外（NIR）成像技术。该系统是同类设备中第一个提供跨NIR范围的多个（五个）波长采样的设备。该技术包括一个离散的“瓷砖”阵列（见下图），其中嵌入了三个多波长LED和四个光电二极管检测器。这些都是基于一个更简单的瓷砖设计，已成功地转化为商业设备的Gowerlabs。我们的跨学科研究实验室NeoLAB位于剑桥的Evelyn围产期成像中心（EPIC），包括来自UCL和剑桥的研究人员。NeoLAB率先开发了新型光子成像系统和方法，并将其应用于新生儿大脑的研究。与UCL分拆的Gowerlabs Ltd合作，我们目前正在开发完全可穿戴的近红外（NIR）成像技术。该系统是同类设备中第一个提供跨NIR范围的多个（五个）波长采样的设备。该技术包括一个离散的“瓷砖”阵列（见下图），其中嵌入了三个多波长LED和四个光电二极管检测器。这些都是基于一个更简单的瓷砖设计，已成功地转化为商业设备的Gowerlabs。该项目的主要目的是成功地证明新系统作为一种有效的临床设备。新颖性该项目产生的光学成像技术是新颖的，它有可能为人类神经生理学提供新的见解，具有神经科学和临床潜力。该项目如何满足CEPS CDT的职权范围开发用于生物医学应用的新光子技术是主要研究之一CDT的主题。该项目将包括电子学、算法开发、软件工程以及对一种用于人脑成像的新型光子系统的实验评估。行业或临床演示该项目将涉及与由顾问神经学家Topun Austin教授领导的剑桥临床团队的合作，以及与衍生公司Gowerlabs Ltd.的研究人员的合作，该公司正在开发用于大脑成像的近红外光子系统。

Our interdisciplinary research laboratory, NeoLAB, is based at the Evelyn Perinatal Imaging Centre (EPIC) in Cambridge, and includes investigators from both UCL and Cambridge. NeoLAB has pioneered the development of novel photonic imaging systems and methods, and their application to the study of the newborn infant brain.In collaboration with UCL spinout Gowerlabs Ltd, we are currently developing a fully-wearable near-infrared (NIR) imaging technology. This system is the first device of its kind to provide sampling at multiple (five) wavelengths spanning the NIR range. The technology consists of an array of discrete "tiles" (see figure below) in which three multi-wavelength LEDs and four photodiode detectors are embedded. These are based on a much simpler tile design which has been successfully translated into a commercial device by Gowerlabs. The primary aim of this project is to successfully demonstrate the new system as an effective clinical device.Our interdisciplinary research laboratory, NeoLAB, is based at the Evelyn Perinatal Imaging Centre (EPIC) in Cambridge, and includes investigators from both UCL and Cambridge. NeoLAB has pioneered the development of novel photonic imaging systems and methods, and their application to the study of the newborn infant brain.In collaboration with UCL spinout Gowerlabs Ltd, we are currently developing a fully-wearable near-infrared (NIR) imaging technology. This system is the first device of its kind to provide sampling at multiple (five) wavelengths spanning the NIR range. The technology consists of an array of discrete "tiles" (see figure below) in which three multi-wavelength LEDs and four photodiode detectors are embedded. These are based on a much simpler tile design which has been successfully translated into a commercial device by Gowerlabs. The primary aim of this project is to successfully demonstrate the new system as an effective clinical device.NoveltyThe optical imaging technology resulting from this project is novel, and it has the potential to provide new insights in to human neurophysiology, with both neuroscientific and clinical potential.How the project meets the remit of the CEPS CDTThe development of new photonic technologies for biomedical applications is one of the major research themes of this CDT. This project will incorporate electronics, algorithm development, software engineering, and experimental evaluation of a novel photonics system for imaging the human brain.Industry or clinical engagementThe project will involve collaboration with the Cambridge-based clinical team led by consultant neonatologist Prof. Topun Austin, as well as collaboration with researchers working with a spin-out company Gowerlabs Ltd., which is developing near-infrared photonic systems for brain imaging.