Soluble Peracid Powders for Medical Device Disinfection

描述(申请人提供)：内窥镜的高度专业化用途及其高昂的资本支出使大多数设备无法拥有非常多的内窥镜。因此，有必要对内窥镜进行快速清洗和消毒，以便它们可以重复使用。内窥镜的这种快速转变对快速清洁和消毒方法提出了很高的要求。最流行的内窥镜消毒方法是将内窥镜浸泡在市售的液体化学杀菌剂中，该杀菌剂含有稀释浓度的戊二醛或过氧乙酸。然而，戊二醛是有毒的，使用戊二醛需要的消毒周期太长。过氧乙酸型杀菌剂的消毒速度要快得多，但由于它们在稀溶液中的稳定性较差，这些杀菌剂被储存为危险的浓缩液。这项修订的第一阶段提案描述了对一种新的过氧化合物家族及其消毒内窥镜的能力的评估。这些化合物可以合成和分离成固体、浓缩的粉末，并延长货架寿命。这种粉末可溶于水，因此，如果需要，可以安全而容易地制备大量液体消毒剂。这些过氧化合物提供了过氧乙酸的理想特性以及浓缩粉的安全和方便特性。 关键词：内窥镜、灭菌、过氧酸、孢子、消毒、冷消毒剂、过氧化合物、液体化学杀菌剂。 商业应用：这项技术的商业应用相当可观。与目前工业中使用的危险浓缩液相比，固体过氧化合物将是首选。从廉价的起始原料一步合成这些化合物是简单的。拟议的技术将首先引入内窥镜后处理行业，然后再引入其他高水平的消毒市场。

DESCRIPTION (provided by applicant): The highly specialized uses for endoscopes and their high capital expense preclude most facilities from owning very many of them. Therefore, it is necessary to rapidly clean and disinfect endoscopes so they can be reused. This rapid turn-around of endoscopes places a high premium on expeditious cleaning and disinfection methods. The most popular method of disinfecting endoscopes is to immerse them in a commercially available liquid chemical germicide that contains dilute concentrations of either glutaraldehyde or peracetic acid. However, glutaraldehyde is toxic and disinfection cycles that use glutaraldehyde require are too long. Peracetic acid-based germicides disinfect much faster but because of their poor stability in dilute solutions, these germicides are stored as hazardous concentrated liquids. This revised Phase I proposal describes the evaluation of a novel family of peroxygen compounds and their capability to disinfect endoscopes. These compounds can be synthesized and isolated as solid, concentrated powders with an extended shelf-life. The powders are soluble in water so that large quantities of liquid disinfectant can be safely and easily prepared, when desired. These peroxygen compounds provide the desirable properties of peracetic acid with the safe and convenient properties of a concentrated powder. Key Words: Endoscope, sterilization, peracids, spores, disinfection, cold sterilants, peroxygen compounds, liquid chemical germicides. Commercial Applications: The commercial applications for this technology are considerable. The solid peroxygen compounds will be preferred over the hazardous concentrated solutions currently used in the industry. The one-step synthesis of these compounds from inexpensive starting materials is straightforward. The proposed technology will be first introduced into the endoscope reprocessing industry and will be followed by the introduction into other high-level disinfection markets.