DEVELOPMENTAL ADAPTATION

描述（根据申请人的描述改编）：儿童计划 儿科系健康研究职业发展奖 耶鲁大学医学院旨在提供密集的基础 研究经验，准备年轻的儿科研究员和教师， 在生物医学研究和学术方面的富有成效和独立的职业生涯 儿科.这次提案的主题是发展适应。继续 十年前，随着Yal Child的成立， 健康研究中心P30赠款和利用现有的专业知识， 心、肺、脑发育、免疫个体发育等相关部门 反应及其与儿童期病原体的相互作用， 缺氧模型这一主题还促进了富有成效和持续的 与细胞生物学，遗传学，免疫生物学， 分子生物学和生物物理学，分子，细胞和发育 生物学和生理学;每个部门的成员都有地方 我们的顾问委员会或列入我们的导师。 该计划将提供灵活的基础研究经验， 支持年轻的儿科科学家通过学院互动与井 资深科学家（导师），由 新的项目开发奖，通过每周在YCHRC的核心讲座， 并通过分子生物学和细胞成像的COR实验室， 在YCHRC。CHRCDA学者的选择继续具有高度竞争性 并从一个合格的研究员补充池谁自己有 在专科培训期间进行基础研究。总的来说， 该计划旨在建立在CHRC机制过去成功的基础上， 通过集中核心设施和课程， YCHRC通过利用研究项目之间的现有互动， 在机构内，并受益于招聘基地的高度 合格的申请人。

DESCRIPTION (Adapted from the applicant's description): A program of Child Health Research Career Development Awards in the Department of Pediatrics at Yale Universit School of Medicine is designed to provide intensive basic research experience to prepare young pediatric fellows and faculty for productive and independent careers in biomedical research and academic pediatrics. The theme of this proposal, Developmental Adaptation. continues the emphasis established ten years ago with the inception of the Yal Child Health Research Center P30 grant and capitalizes on extant expertise in the Department regarding heart, lung and brain development, ontogeny of the immune response and its interactions with childhood pathogens, an developmental models of hypoxia. This theme also catalyzes productive and on-going collaborations with th Departments of Cell Biology, Genetics, Immunobiology, Molecular Biology and Biophysics, Molecular, Cellular an Developmental Biology, and Physiology; members of each of these departments have places on our Advisor Committee or are listed among our mentors. The proposed program will provide flexible basic research experience and support for young pediatri scientists through collegial interactions with well established senior scientists (mentors), through start-up fundin provided by new project development awards, through the weekly core lectures at the YCHRC, and through cor laboratories in molecular biology and cellular imaging located at the YCHRC. Selection of CHRCDA Scholars continue to be highly competitive and to draw from a replenishing pool of qualified fellows who themselves have undertaken basic research during subspecialty training. Overall, the CHRCDA program intends to build on the past success of the CHRC mechanism and to enhance its productivity by centralization of core facilities and curriculum a the YCHRC, by leveraging the existing interactions among research programs within the institution, and by benefitin from a recruitment base of highly qualified applicants.