Solid polypeptide dosage forms for transdermal and subcutaneous administration

该项目旨在开发多肽(肽和蛋白质)制剂，用于经皮和皮下(Sc)给药。模型多肽将被配制并与辅料一起加工，这些辅料已被证明可以将蛋白质稳定为固体颗粒。载药颗粒将使用乳化液和电喷雾工艺制造。辅料将包括普通聚合物和低分子分子(如缓冲液、氨基酸)。我们将探索处方和加工策略，在保持多肽功能的同时实现受控和缓释。固体、稳定颗粒给药的剂型设计将包括用于经皮给药的微针和作为皮下注射颗粒库系统的微针。

The project aims to develop polypeptide (peptide and protein) formulations for transdermal and subcutaneous (sc) delivery. Model polypeptides will be formulated and processed with excipients that have been shown to stabilise proteins as solid particles. Drug loaded particles will be fabricated using emulsion and electrospraying processes. The excipients will include common polymers and low molecular weight molecules (e.g. buffers, amino acids). We will explore formulation and processing strategies to achieve controlled and extended release while maintaining polypeptide function. Dosage form design for administration of the solid, stabilised particles will be examined including microneedles for transdermal administration and as an subcutaneously injectable particle depot system.