Core--Vector

在本中心的当前周期中，载体核心经历了实质性的发展，以利用在新型病毒载体方面取得的巨大进展。王丽丽博士是从因德·维尔马博士的实验室招募来指导载体核心的。在过去四年中，矢量核心提供的服务清单呈指数级增长。在上次更新赠款时，中心提供的服务是基于血清5型腺病毒、血清2型腺相关病毒（AAV）和基于鼠的生态嗜性和两性嗜性逆转录病毒的载体。核心提供的服务清单已扩大到包括：腺病毒-基于人类Ad5和至少5种猿类腺病毒的载体；AAV-基于人类AAV血清型1、2和5以及猿猴AAV血清型7和8的载体，该列表扩展到

The Vector Core has undergone substantial evolution during the current cycle of the Center to leverage the tremendous progress that has been made in novel viral vectors. Dr. Lili Wang was recruited from Dr. Inder Verma's laboratory to direct the Vector Core. During the last four years, the list of services provided from the Vector Core has expanded exponentially. At the time of the last renewal of the grant the core provided services with vectors based on adenovirus serotype 5, adeno-associated virus (AAV) serotype 2 and murine based ecotropic and amphotropic retroviruses. The list of services provided by the core has expanded to include: Adenovirus - vectors based on human Ad5 and at least 5 simian adenoviruses; AAV- vectors based on the human AAV serotypes 1,2 and 5 and simian AAV serotype 7 and 8 with this list expanding to include 10 additional AAV serotypes over the next cycle of the grant; lentiviruses - at least 6 different pseudotypes based on HIV and FIV; and murine retroviruses - various pseudotypes.