Evaluation of the Obesity Paradox in Diabetes: A Longitudinal Case-Control Study of Half a Million Patients

肥胖是患糖尿病的一个风险因素。然而，最近的研究报告称，与超重或肥胖患者相比，糖尿病患者与正常体重相关的死亡风险增加。这种“肥胖悖论”，即超重似乎是有保护作用的，在糖尿病中是新出现的。这背后的机制尚不清楚。这项研究利用对50万名糖尿病患者和对照患者20年的随访数据，提出了在肥胖悖论背后寻找可能的解释。

Obesity is a risk factor for developing diabetes. However, recent studies reported increased mortality risk associated with normal body weight in people with incident diabetes compared to overweight or obese patients. This “obesity paradox”, where being overweight appears to be protective, is new in diabetes. The mechanism behind this is not known. Using 20 years of follow-up data on 500,000 diabetes and control patients, this study proposes to find possible explanations behind obesity paradox.