Improving Energy Cost Estimation of Physical Activity

描述（由申请人提供）： 通过这项申请，该研究职业奖（K25）的候选人寻求在进行人类研究方面的额外培训，特别强调应用工程技术来改善自发体育活动（PA）的能源成本估计。他的近期目标是在生物医学研究和临床调查方面发展更多的专业知识;他的最终目标是开发一个独立的研究项目，评估PA和能量消耗（EE），因为它与肥胖和代谢综合征有关。 自发性PA是总EE的重要组成部分。日常活动（如坐、站和躺）的能量需求已被广泛研究。然而，许多自发活动的能源成本，如坐立不安和活动之间的转换，这是众所周知的实质性有助于能源平衡，还没有得到很好的研究和量化。为了完成准确的24小时EE评估，重要的是开发有效的方法来评估这些活动。 本申请的具体目的是：1）通过开发用于机械功和能量成本计算的40种自发活动中的每一种的数学模型来量化自发PA并改善自由生活个体中PA的能量成本估计。2)使用间接量热法和大型测力平台对上述模型和方法进行校准和验证。这些研究将提高现有技术的能源成本估计的整体准确性，并提供技术来量化某些自发活动对能源消耗的影响。为有效、准确地评估日常PA提供了一种方便、实用的方法。 获得每日PA的定量信息的能力将有助于专家和医生制定和评估促进PA用于改善健身和治疗肥胖以及其他疾病的策略。

DESCRIPTION (provided by applicant): Through this application, the candidate for this Research Career Award (K25) seeks additional training in conducting human research, with a special emphasis on applying engineering techniques to improve the estimation of energy cost of spontaneous physical activities (PA). His immediate goal is to develop additional expertise in biomedical research and clinical investigation; his ultimate goal is to develop an independent research program in assessment of PA and energy expenditure (EE) as it relates to obesity and the metabolic syndrome. Spontaneous PA is a significant part of total EE. Energy requirements of usual activities, such as sitting, standing and lying down have been studied extensively. However, the energy costs for many spontaneous activities, such as fidgeting and transitions between activities, which are known to substantively contribute to energy balance, have not been well studied and quantified. It is important to develop effective methods to assess those activities in order to complete accurate 24-hour EE assessment. The specific aims of this application are: 1) To quantify spontaneous PA and improve energy cost estimation of PA in free-living individuals by developing mathematical models of each of 40 spontaneous activities for mechanical work and energy cost calculation. 2) To calibrate and validate the above models and methods with subjects performing various activities using indirect calorimetry and a large force platform. These studies will improve the overall accuracy for energy cost estimation of the existing technology and provide the techniques to quantify the impact of certain spontaneous activity on energy expenditure. It also will provide a convenient and practical method to assess daily PA effectively and accurately. The ability to obtain quantitative information of daily PA will assist specialists and physicians in developing and evaluating strategies to promote PA for improving fitness and treating obesity as well as other diseases.