HYPERTENSION AMONG AFRICAN-AMERICANS

描述(由申请人提供)：调查人员？目标是成为一名 临床医生兼科学家专注于非裔美国人的健康和高血压 使用群体遗传学、分子生物学和血液学工具进行研究 压力(BP)生理学。为了实现他的目标，他设计了一个程序 课程，由高级调查人员进行的结构化指导，以及创新 研究。关于继续学习，他被授予大师S 今年获得流行病学健康科学学位，并将继续进修 JHU和JH Bloomburg公共卫生学院的实地课程 种群遗传学和分子生物学。此外，他还将继续 每周与他的赞助人会面，定期与他的顾问会面 高级调查员委员会。 在他的赞助人和合作调查人员的支持下，他提出了一项 300例非裔美国人重度高血压病例对照研究 住进JH医院的200名血压正常的兄弟姐妹和300名 有高血压家族史的社区居民对照 在相隔四年的两个时间点测量的正常低血压。这个 基因变异和候选暴露的流行率将在以下方面进行比较 箱子和两套控制装置。此外，调查人员将 研究基因与基因和基因与环境的相互作用。通过一个新的 与阿拉文达·查克拉瓦蒂博士和麦库西克-纳桑夫妇合作 遗传医学研究所(IGM)的这项研究将受益于先进的 基因分型技术将允许识别数百名 数百个基因座的等位基因。 这项研究的特点是招募了代表 BP分布的极端，兄弟控制的招募， 近端表型的表征，环境的测量 暴露，以及使用先进的基因分型技术。此外， 纳入市中心的非洲裔美国人将填补 了解BP规则。这项雄心勃勃的研究之所以可行，是因为 政府间机制核心实验室的基础设施--GCRC的支持， 调查员？S 10年来与社会的关系，他展示了 招聘的成功，以及他导师和赞助商的承诺。这 研究将为独立人士的成功职业生涯奠定基础 调查员。

DESCRIPTION (provided by applicant): The investigators? goal is to become a clinician-scientist focused on African-American health and hypertension research using the tools of population genetics, molecular biology, and blood pressure (BP) physiology. To realize his goal, he designed a program of coursework, structured mentoring by senior investigators, and innovative research. With regards to continuing coursework, he was awarded a Master?s degree in health science in epidemiology this year and will continue advanced coursework at JHU and the JH Bloomburg School of Public Health in the fields of population genetics and molecular biology. In addition, he will continue to meet weekly with his sponsor and to meet regularly with his Advisory Committee of senior investigators. With the support of his sponsor and co-investigators, he proposes a case-control study of 300 African-American persons with severe hypertension admitted to the JH Hospital, 200 normotensive siblings, and 300 community-dwelling controls with a negative family history of hypertension and a low normal BP measured at two points in time four years apart. The prevalence of gene variants and candidate exposures will be compared between the cases and two sets of controls. In addition, the investigators will investigate gene-gene and gene-environment interactions. Through a newly formed collaboration with Dr. Aravinda Chakravarti and the McKusick-Nathans Institute of Genetic Medicine (IGM), the study will benefit from advanced genotyping technology that will allow the identification of hundreds of alleles at hundreds of loci. This study is distinguished by the recruitment of individuals representing extremes of the BP distribution, the recruitment of sibling controls, the characterization of proximal phenotypes, measurement of environmental exposures, and the use of advanced genotyping technology. In addition, the inclusion of inner city African-Americans will fill a major gap in the understanding of BP regulation. This ambitious study is feasible because of support from the GCRC, the infrastructure of the Core Laboratory of the IGM, the investigator?s 10-year relationship with the community, his demonstrated recruitment success, and the commitment of his mentors and sponsor. This research will build a foundation for a successful career as an independent investigator.