Applications of nanodiamond for adaptive-optics corrected super-resolution imaging

超分辨率成像技术允许研究远小于传统限制的结构，传统限制约为光波长的一半。2014年诺贝尔化学奖强调了其对生物科学的重要性。我们开发的显微镜可以在生物样品中进行超分辨率成像;然而，对于成功的成像仍然存在许多挑战，例如光学不均匀性对成像过程的影响，用合适的染料对感兴趣的结构进行有效标记，以及希望进一步提高采集速度，视场，成功的学生将有机会发展广泛的技能，这些技能对下一代显微镜的研究至关重要，例如，开发纳米金刚石作为活组织中的光学传感器，以及使用自适应光学器件来校正生物相关样品中的像差。成功的候选人将获得广泛的技能经验，如：光学硬件设计和校准，开发硬件控制和数据处理软件，标记成像样品，并与生物科学领域的同事合作，以确保我们的研究也能够实现新的生物科学。

Super-resolution imaging techniques allow studying of structures much smaller than the traditional limit of approximately half the wavelength of the light. The 2014 Nobel Prize in Chemistry has emphasised its fundamental importance to the biological sciences. We develop microscopes that can perform super-resolution imaging within biological samples; however there are still numerous challenges to successful imaging such as the effects of optical inhomogeneities on the imaging process, effective labelling of structures of interest with suitable dyes and the desire to further increase speed of acquisition, field of view, resolution and perform multi-colour imaging in 3D.The successful student will have the opportunity to develop a wide range of skills that are essential for performing research into next-generation microscopy, e.g. developing nanodiamond as an optical sensor in living tissue and the use of adaptive optics to correct for aberrations in biologically relevant samples. Successful candidates will gain a wide range of experience in skills such as: Optical hardware design and alignment, developing software for hardware control and data processing, labelling samples for imaging and collaboration with colleagues in the biological sciences to ensure our research also enables new biological science.